L-Citrulline Protects against Rhabdomyolysis -Induced Acute Renal Failure in Rats

Xiao Bin Fu; Sai Li; Li Liu; Ling Shan Gou; Nuo Lan; Ling Wang; Yan Feng; Yi Liu

doi:10.4028/www.scientific.net/AMR.634-638.1323

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 634-638L-Citrulline Protects against Rhabdomyolysis...

L-Citrulline Protects against Rhabdomyolysis -Induced Acute Renal Failure in Rats

Abstract:

There is increasing evidence indicating that oxidative stress plays an important role in the pathogenesis of rhabdomyolysis-induced myoglobinuric acute renal failure (ARF). In this study, protective effects of L-citrulline on glycerol-induced acute renal failure (ARF) in rats were investigated. Six groups of rats were employed in this study, after seven days of glycerol injections, the blood samples and kiney tissues were harvested for future biochemical and pathology analysis. The levels of creatinine (Cr) and urea nitrogen (BUN) in plasma, the content of malondialdehyde (MDA), glutathione (GSH), nitric oxide (NO), the activity of total nitric oxide synthase (TNOS), inducible nitric oxide synthase (iNOS), endothelial NO synthase (eNOS) and superoxide dismutase (SOD) were evaluated in kiney tissues. Consequently, treatment with L-citrulline improved an impaired intrarenal oxygenation and kidney function compare with the glycerol group, and prevented the renal oxidative stress damage as well as severe functional and morphological renal deterioration.

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Advanced Materials Research (Volumes 634-638)

Pages:

1323-1327

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.634-638.1323

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Online since:

January 2013

Authors:

Xiao Bin Fu, Sai Li, Li Liu, Ling Shan Gou, Nuo Lan, Ling Wang, Yan Feng, Yi Liu

Keywords:

ARF, Glycerol, iNOS, L-Citrulline, NO

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