A Study of Amplifying Ovarian Cancer Biomarkers Concentration by an Ultrasonic Device

Abstract:

This paper reported a method of amplifying ovarian biomarkers concentration. Ultrasound device radiated to ovarian cancer cell to amplify the concentration of the biomarkers in the blood, achieving early diagnosis of ovarian cancer. The device used digital frequency generator technique and adaptive load technology to produce frequency(1MHz), duty cycle (50%), power(0.3W/cm2). This study used the device to produce ultrasound exposure on vitro ovariancancer cell and determined the concentration of CA125 and CA19-9 in the blood after ultrasound exposure. The results show that the device can produce stable frequency and ultrasound power. The device radiated vitro ovarian cancer cell 5min, the biomarker CA125 concentration amplified 2.02 fold and CA19-9 concentration amplified 4.21 fold compare with no radiation ovarian cancer cell. This project developed a device for amplifying ovarian cancer biomarkers concentration which can amplify two or more biomarkers concentration simultaneously.

• Periodical: Advanced Materials Research (Volumes 634-638)
• Pages: 1332-1337
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.634-638.1332
• Online since: January 2013
• Authors: Yi Xin Sun, Tian Xu, Dan Hong Pen, Jian Fu, Wei Wu
• Keywords: Amplification, Biomarkers, Ovarian Cancer, Ultrasonic Device

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