Application of Data Mining Technology on Analyzing a Series of Biomarkers for Diagnosis of Bone Metastasis from Different Cancers

Abstract:

The aim of this study was to evaluate the value index of tumor biomarkers for diagnosis and prediction of bone metastasis by combining pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen (ICTP) in serum with other biochemical markers in patients with several cancers. All of 1253 patients and biomarkers data with cancers and the related benign diseases and 312 healthy controls were included in the study. Bioinformatics, data mining technology and statistics were carried out to calculate sum of direct positive index (SDPI) and sum of indirect positive index (SIPI). The average ICTP was higher in patients with bone metastasis from liver, gastric, lung, colorectal and pancreatic cancer, than in cancer patients without bone metastasis. For those cancers patients with bone metastasis, which could not be differentiated by single ICTP, combining with SDPI and SIPI would distinguish types of carcinama in situ from similar symptoms. The measurement of multiple tumor markers was very useful in complementary diagnosis and prediction of different carcinoma with bone metastasis bottom.

• Periodical: Advanced Materials Research (Volumes 634-638)
• Pages: 1338-1342
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.634-638.1338
• Online since: January 2013
• Authors: Da Lin Wang, Cheng Ma, Zheng Yu Wu, Gang Wang, Ming Cheng Li
• Keywords: Biomarkers, Bone Metastasis, Data Mining (DM)

References

[1] Molina R, Bosch X, Auge JM, et al. Tumour Biol 33(2): 463-474. (2012).

[2] Takahiko H, Soichi T and Rieko. J Clin Oncol 30(4): 174-179. (2000).

[3] Michael K, Mitchell L, Paul C, et al. Can J Surg 55(2): 95-98. (2012).

[4] Wedin R, Bauer HCF. J Bone and Joint Surg Br 87: 1653-7. (2005).

[5] Wilkinson AN, Viola R, Brundage MD. BMJ 337: 2041. (2008).

[6] Healey JH, Brown HK. Cancer 88(Suppl): 2940-2951. (2000).

[7] Jacofsky DJ, Haidukewych GJ. J Orthop Trauma 18: 459-469. (2004).

[8] Eckardt JJ, Kabo JM and Kelly CM. Clin Orthop Relat Res (415 Suppl): S254-262. (2003).

[9] Bildirici U, Celikyurt U, Acar E, et al. Cardiovasc J Afr. 23(3): 143-146. (2012).

[10] Joerger M, Huober J. Recent Results Cancer Res. 192: 197-223. (2012).

[11] Fuchs B, Trousdale RT, Rock MG. Clin Orthop Relat Res 431: 187-92. (2005).

[12] Franjević A, Pavićević R, Bubanović G. Coll Antropol. 35(1): 43-7. (2011).

[13] Zhang W, Yang HC, Wang Q, et al. Anticancer Res. 31(10): 3423-3428. (2011).