Theoretical and Experimental Studies of Bio-Detection Areas Used in Centrifugal Microfluidic Platforms

Abstract:

The CD-ELISA is a self-contained micro-device that incorporates low-power micro-fluidic components and high-sensitivity immune-molecules, and is capable of performing parallel and multiple tests with high precision. The CD platform integrates number of micro-fluidic functions. Bio-detection area is the most important region which directly affects measurement results. In this study, both theoretical and experimental results were compared to show the feasibility design of bio-detection region.

• Periodical: Advanced Materials Research (Volume 647)
• Pages: 386-390
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.647.386
• Online since: January 2013
• Authors: I En Lin, Yi Ling Ye, Ding Yuan Liang, Bang Wei Chen
• Keywords: Centrifugal, Compact Disc (CD), Detection Area, ELISA, Micro-Fluidics

References

[1] Madou M, Lee L, Daunert S, Lai S, Shih C, Design and Fabrication of CD-like Microfluidic Platforms for Diagnostics: Microfluidic Functions, Biomedical Microdevices 2001, 3(3): 245-254.

DOI: 10.1023/a:1011419515576

[2] Yuan Yuan, He Hongyan, Lee L James, Protein A-based antibody Immo-bilization onto polymeric microdevices for enhanced sensitivity of enzyme-linked immunosorbent assay, Biotechnology and Bioengineering 2009, 102(3): 891-901, 15.

DOI: 10.1002/bit.22136

[3] Samuel I En Lin, Novel bifurcation design for centrifugal microfluidic platform with wide range rotational speed, Department of Power Mechanical Engineering, Journal of Nanotechnology in Engineering and Medicine, published 13 December (2010).

DOI: 10.1115/1.4002748

[4] Samuel I En Lin, A novel splitter design for microfluidic biochips using centrifugal driving forces, MicrofluidNanofluid (2010) 9: 523–532.

DOI: 10.1007/s10404-010-0568-5