Gene Polymorphism and Precocious Puberty: A Meta-Analysis of Case-Control Studies

Abstract:

Objective: To reexamine literature and data on the effects of gene polymorphism on precocious puberty via a meta-analysis. Methods: Consultation of search engines Chinese Bio-medicine Database, China National Knowledge Infrastructure, Pubmed and Medline search resulted in a total of seven studies containing more than 4300 individuals from various ethnic backgrounds. To evaluate the risk of precocious puberty, odds ratios (OR) for all case-control studies were calculated. Results: In this meta-analysis no significant association of the gene polymorphism with precocious puberty in the combined case-control sample (OR=1.19, 95%CI: 0.88-1.62, P=0.26) was found. Conclusion: This study found no evidence of gene polymorphism being an independent risk factor of precocious puberty. Further studies are needed further understand the effects of the interactions between these genes and other genetic and/or environment factors on precocious puberty.

• Periodical: Advanced Materials Research (Volume 647)
• Pages: 466-470
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.647.466
• Online since: January 2013
• Authors: Min Jie Zhang, Zong Lin Gong, Di Han, Xiang Gao, Qi Tan, Yong Xu
• Keywords: Gene, Meta Analysis, Polymorphism, Precocious Puberty

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