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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 669Oxidative Damage of Brain Induced by Nano-CdSeS in...

Oxidative Damage of Brain Induced by Nano-CdSeS in Mice

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Abstract:

In this experiment, the oxidative damage of nano-CdSeS in mice brains was performed. 20 male Kunming mice were divided into 4 groups and 3 experimental groups were exposed to different doses of nano-CdSeS (0.1 mg/mL, 0.2 mg/mL and 0.4 mg/mL) by intravenous administration while the control used saline solution instead. Three days later, the enzymatic activity of superoxide dismutase (SOD), the content of malondialdehyde (MDA) and the damage degree of DNA were determined to assess the oxidative damage in brain tissues. Our results showed that in the experimental groups, SOD activity was inhibited and MDA content was increased as the doses rising, at the same time, tail moment and tail DNA% increased significantly when comparing with the control. And these results exhibited a certain doses-dependency relations. From results above, it demonstrated that oxidative damage of brain induced by nano-CdSeS which enter into blood–brain barrier in mice.

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Periodical:

Advanced Materials Research (Volume 669)

Pages:

316-324

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.669.316

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Online since:

March 2013

Authors:

Shang Yue Yang, Ran Feng Ye, Wen Jun Cai, Xiao Ling Xiang, Xu Yang

Keywords:

Brain, Comet Assay, Malondialdehyde (MDA), Mouse, Nano-CdSeS, Oxidative Damage, Superoxide Dismutase (SOD)

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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