Design, Synthesis and Biological Activity Evaluation of Novel N-Acylation Substituted Isatin Derivatives

Bin Zeng; Xiao Hua Zhu

doi:10.4028/www.scientific.net/AMR.683.34

Paper Titles

Investigation for the Fracture Process of WC_p/Cu Functionally Graded Materials under Three-Point-Bending
p.17

Properties and Performance Analysis of Woven Roving Composite Laminates for Automotive Panel Board Applications
p.21

Study on Synthesis of Cyclotriphosphazene Containing Aminopropylsilicone Functional Group as Flame Retardant
p.25

Synthesis of SiO₂/CeO₂ Nanopaticles with Core/Shell Structure and Their Polishing Performance
p.30

Design, Synthesis and Biological Activity Evaluation of Novel N-Acylation Substituted Isatin Derivatives
p.34

TiO₂ Immobilized in RPF-AA Fiber for Photocatalytic Degradation of Low Concentration Methylene Blue in Aqueous Solution
p.38

Study on the ZnO-B₂O₃-SiO₂ Glass-Ceramic with DTA, XRD and SEM
p.42

A Review on the Methods of Improving Fiber Distribution of Engineered Cementitious Composites (ECC)
p.46

The Influence of Tread Material Oil Aging on Tire Performance
p.51

HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 683Design, Synthesis and Biological Activity...

Design, Synthesis and Biological Activity Evaluation of Novel N-Acylation Substituted Isatin Derivatives

Abstract:

Isatin, an endogenous compound existent in many organisms, shows a wide range of biological activities. In this paper, we like to report the design and synthesis of several isatin derivatives through the acetalization and N-Acylation. Six newly synthesized compounds were characterized on the basis of 1H NMR, and those compounds were determined using two different human cancer cell . Anti-cancer activity showed those compounds IC50＜50 μm.

You might also be interested in these eBooks

Advanced Materials and Engineering Materials II

View Preview

Info:

Periodical:

Advanced Materials Research (Volume 683)

Pages:

34-37

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.683.34

Citation:

Cite this paper

Online since:

April 2013

Authors:

Bin Zeng, Xiao Hua Zhu

Keywords:

Anti-Cancer Activity, Isatin Derivatives, N-Acylation Reaction

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

References

[1] Glover V. Function of endogenous monoamine oxidase inhibitors (tribulin). J Neural Transm Suppl 1998; 52: 307-313.

DOI: 10.1007/978-3-7091-6499-0_31

Google Scholar

[2] Watkins, P.; Clow, A.; Glover, V.; Halket, J.; Przyborowska, A.; Sandler, M. Isatin, regional distribution in rat brain and tissues. Neurochem. Int. 1993; 17: 321-323.

DOI: 10.1016/0197-0186(90)90154-l

Google Scholar

[3] Medvedev AE, Goodwin B, Clow A, Halket J, Glover V, Sandler M. Inhibitory potency of some isatin analogues on human monoamine oxidase A and B. Biochem Pharmacol 1992; 44: 590-592.

DOI: 10.1016/0006-2952(92)90454-q

Google Scholar

[4] Seshaiah Krishna Sridhar, Atmakuru Ramesh. Pharm Bull 2001; 24: 1149-1152.

Google Scholar

[5] Neelu Kaila, Kristin Janz, Adrian Huang, Alessandro Moretto, Silvano DeBernardo, Patricia W. Bedard, Steve Tam, Valerie Clerin, James C. Keith, Jr., Desire´e H. H. Tsao, Natalia Sushkova, Gray D. Shaw, Raymond T. Camphausen, Robert G. Schaub, and Qin Wang, J. Med. Chem. 2007; 50: 40-64.

DOI: 10.1021/jm060631p

Google Scholar

[6] Magiatis, P; Skaltsounis, A. -L; Myrianthopoulos, V; Mikros, E; Tarricone, A; Musacchio, A; Roe, S. M; Pearl, L; Leost, M; Greengard, P; Meijer, L. The synthesis of this compound was reported by Polychonopoulos, J. Med. Chem. 2004; 47: 935.

DOI: 10.1021/jm031016d

Google Scholar

[7] V. Raja Solomon, Changkun Hua, Hoyun Lee. Bioorganic & Medicinal Chemistry 2009; 17: 7585–7592.

Google Scholar