Preparation and Characterization of Folate-Decorated Chitosan Microspheres as a Sustained-Release Drugs Carrier

Zhi Hua Xing

doi:10.4028/www.scientific.net/AMR.684.57

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 684Preparation and Characterization of...

Preparation and Characterization of Folate-Decorated Chitosan Microspheres as a Sustained-Release Drugs Carrier

Abstract:

Folic acid-chitosan (FA-CTS) and 10-hydroxycamptothecin (HCPT)-loaded folate-conjugated chitosan (FA-CTS/HCPT) microspheres were prepared by the ionic crosslinking method.The morphological characteristics of microspheres were examined using a scanning electron microscope (SEM). The average particle size and size distribution were determined by dynamic light scattering. The drug encapsulation efficiency (EE) , loading capacity (LC)and release characteristics in vitro were determined using ultraviolet spectrophotometer.The results shown that the microspheres are uniform spherical and regular with a size between 19.79 and81.40μm.Optimized preparation parameters lead to the successful preparation of hydroxycamptothecin-loaded folate-conjugated chitosan microspheres characterized with encapsulation efficiency and loading capacity up to (86.8±0.1)% and 20.6±0.3 % respectively. More then 90% of 10-hydroxycamptothecin was released from microspheres in 4 h at artificial gastric juice, 8h at artificial small intestinal fluid with a good delayed release effect.

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Periodical:

Advanced Materials Research (Volume 684)

Pages:

57-62

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.684.57

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Online since:

April 2013

Authors:

Zhi Hua Xing

Keywords:

Chitosan, Folic Acid, Hydroxycamptothecin, Ionic Crosslinking, Micro-Sphere

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