A Thermal Controlled Release of Naproxen from Sodium Phosphorylated Chitosan Nanoemulsion

Suchada Chongprakobkit; Wanpen Tachaboonyakiat

doi:10.4028/www.scientific.net/AMR.701.217

Paper Titles

Electrical Conductivity and Hardness Property of CNTs/Epoxy Nanocomposites
p.197

Cable and Wire Application: Adoption of Nanomagnesium Hydroxide Blended with LDPE/EVA for Mechanical and Physical Properties
p.202

Thermal Stability Study of Ce_0.75-Zr_0.25O Nanostructures Synthesized via Water-in-Oil Microemulsion Method
p.207

The Effect of Synthesis Method on the Physico-Chemical Properties of Magnetite Iron Oxide Nanoparticles
p.212

A Thermal Controlled Release of Naproxen from Sodium Phosphorylated Chitosan Nanoemulsion
p.217

Flexural and Impact Properties of Biopolymer Derived from Sugar Palm Tree
p.225

Preparation of Biodegradable Film from Esterified Corn Husk Cellulose
p.229

Enhancement the Dissolution Rate and Solubility of Poorly Soluble Drugs: Review
p.234

Effect of Alkali Treatment on the Tensile Behavior and Structure of Betel Nut (Areca catechu) Husk Fiber
p.239

HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 701A Thermal Controlled Release of Naproxen from...

A Thermal Controlled Release of Naproxen from Sodium Phosphorylated Chitosan Nanoemulsion

Abstract:

The aim of this research was to control the delivery of naproxen from emulsion-based sodium phosphorylated chitosan (PCTS) nanoparticles (PCTS nanoemulsion) by thermal stimulus. The dynamic light scattering and optical microscope results demonstrated that the droplet size of emulsion-based nanoparticles was sensitive to temperature. The PCTS nanoemulsion exhibited the droplet size around 230 nm at 30°C. Emulsion droplets were increased in their size over critical temperature of around 60°C. Besides, the droplet size was reversible to 270 nm when the temperature decreased to 30°C. This indicated that the droplet size of PCTS nanoemulsion was sensitive to thermal stimulus. It might owe to molecular chain extension and rearrangement of PCTS at the interface of emulsion droplets. Therefore, the control release of naproxen from PCTS nanoemulsion via thermal stimulus was investigated. In vitro release study showed that the naproxen was released from PCTS nanoemulsion in high amount over critical temperature. These results indicated that the PCTS nanoemulsion exhibited a potential application as intelligent thermal sensitive drug carrier.