Research on Hemocompatibility of Polypropylene Non-Woven Fabric Membrane Immobilized by N-Alkylglucosamides

Abstract:

New types of ecologically benign surfactants with sugar as head groups (N-alkylglucosamides) have been described, namely, N-octylglucosamides (NOGA), N-dodecylglucosamides (NDGA), N-cetylglucosamides (NCGA). N-alkylglucosamides were characterized by Fourier transform infrared spectroscopy (FTIR) and ¹H Nuclear Magnetic Resonance (¹HNMR) respectively. N-alkylglucosamides was immobilized onto the surface of PPNWF by using Glycidyl methacrylate (GMA) as the linking agent. The chemical structure and composition of the modified PPNWF surface were analyzed by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS). The surface properties were investigated by water contact angle. The water contact angles of the modified PPNWF decreased from 111° to 73°. The hemocompatibility of the modified PPNWF was evaluated by platelet adhesion. The number of platelets adhering to the modified surface was more dramatically reduced than that of the virgin surface. The results indicate that the modified surface of PPNWF by N-alkylglucosamides was a facile approach to construct biocompatible surface.

• Periodical: Advanced Materials Research (Volume 704)
• Pages: 301-306
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.704.301
• Online since: June 2013
• Authors: Zhi Rong Xin, Zong Feng Yang, Shun Jie Yan, Bin Bin Du
• Keywords: Hemocompatibility, N-Alkylglucosamides, Polypropylene Non-Woven Fabric Membrane

References

[1] C.C. Wang, F.L. Yang, L.F. Liu, Z.M. Fu, Y. Xue, J. Membr. Sci. 345 (2009) 223–232.

[2] Y. Zheng, H. Liu, P.V. Gurgel, R.G. Carbonell, J. Membr. Sci. 364 (2010) 362–371.

[3] J.Jin, Wei Jiang, Qiang shi,et,al. Fabrication of PP-g-PEGMA-g-heparin and its hemocompa tibility: From protein adsorption to anticoagulant tendency. Applied Surface Science, 2012. 258(15): pp.5841-5849.

DOI: 10.1016/j.apsusc.2012.02.113

[4] L.J Song. Biocompatibility of polypropylene non-woven fabric membrane via UV-induced graft polymerization of 2-acrylamido-2-methylpropane sulfonic acid. Applied Surface Science, 2011. 258(1): pp.425-430.

DOI: 10.1016/j.apsusc.2011.08.118

[5] X.M Li, S.F. Luan, H.W. Yang, et al. Surface modification of poly(styrene-b- -(ethylene-co-butylene)-b-styrene) elastomer via photo-initiated graft polymerization of poly(ethylene glycol). Applied Surface Science, 2012. 258(90): 2344–2349.

DOI: 10.1016/j.apsusc.2011.10.024

[6] J. Zhao, Q. Shi, L.G. Yin, et al. Improved biocompatibility and antifouling property of polypropylene non-woven fabric membrane by surface grafting zwitterionic polymer. Journal of Membrane Science, 2011. 369(1-2): pp.5-12.

DOI: 10.1016/j.memsci.2010.10.046

[7] Z.Q. Wu, H. Chen, H. Huang, T.L. Zhao, X.L. Liu, D. Li, Q. Yu, Macromol. Biosci. 9(2009) 1165–1168.

[8] Z. M. Liu, Z.K. Xu, J.Q. Wang, J.Wu, J.J. Fu, Eur. Polym. J. 40(2004)2077–2087.

[9] S.Zanini, C. Riccardi, E. Grimoldi, C. Colombo, A.M. Villa, A. Natalello, P. GattiLafranconi, M. Lotti, S.M. Doglia, J. Colloid Interface Sci. 341 (2010)53–58.

DOI: 10.1016/j.jcis.2009.09.012

[10] Y.F. Yang, Y. Li, Q.L. Li, L.S. Wan, Z.K. Xu, J. Membr. Sci. 362(2010)255–264.

[11] F. Fazio, et al. Synthesis of Sugar Arrays in Microtiter Plate. J. AM. CHEM. SOC. 9 VOL. 124, NO. 48, 2002.

[12] S. Saxena, A.R. Ray, and B. Gupta, Chitosan immobilization on polyacrylic acid grafted poly -propylene monofilament. Carbohydrate Polymers, 2010. 82(4): pp.1315-1322.

DOI: 10.1016/j.carbpol.2010.07.014

[13] Y.B. Chen and S.Thayumanavan. Amphiphilicity in Homopolymer Surfaces Reduces Nonspecific Protein Adsorption. Langmuir,2009, 25(24): 13795–1379.

DOI: 10.1021/la901692a

[14] B.S.H. Baxamusa, K. K. Gleason. Random Copolymer Films with Molecular- -Scale Compositional Heterogeneities that Interfere with Protein Adsorption. Adv. Funct. Mater. 2009,19, 3489–3496.

DOI: 10.1002/adfm.200900943

[15] L. Syper, K.A Wilk, A.Sokotowski, et.al. Synthesis and surface properties of N-alkylaldon- -amides. Progr Colloid Polym Sci (1998) 110:199-203.

[16] Burton, E.-L., et al. Reactive grafting of glycidyl methacrylate onto polypropylene. Journal of Applied Polymer Science, 2010: p. n/a-n/a.

[17] J.W. Cho, S.K. Yadav, S.S. Mahapatra, J.Y. Lee, J. Phys. Chem. C 114 (2010)11395–11400.

[18] S.F. Luan, J. Zhao, H.W. Yang, et al. Surface modification of poly (styrene-b- (ethylene-co-butylene)-b-styrene) elastomer via UV-induced graft polymerization of N-vinyl pyrrolidone. Colloids and Surfaces B: Biointerfaces 93 (2012) 127– 134.

DOI: 10.1016/j.colsurfb.2011.12.027