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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 704Interaction Mechanism between Bovine Serum Albumin...

Interaction Mechanism between Bovine Serum Albumin and Polyethylene Glycol Revealed with Elastic Light Scattering Spectroscopy

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Abstract:

In order to gain deeper insight into the interaction mechanism between bovine serum albumin (BSA) and polyethylene glycol (PEG), the present work applied elastic light scattering (ELS) spectroscopy to investigate the interaction between BSA and PEG, and explore the effects of concentration and molecular weight of PEG on the interaction at physiological pH. The results showed that the interaction force existed between linear PEG and spherical BSA molecules was mainly hydrogen bonding. In addition, the apparent binding constant of system was evaluated by model calculation.

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2013 Spring International Conference on Material Sciences and Technology (MST-S)

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Periodical:

Advanced Materials Research (Volume 704)

Pages:

43-50

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.704.43

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Online since:

June 2013

Authors:

Wen Zhi Zhang, Kuan Zhang, Jian Long Zheng, Hong Shu Chen, Wei Xing Chen, Xin Li Jing

Keywords:

Binding Constant, Bovine Serum Albumin (BSA), Elastic Light Scattering Spectroscopy, Interaction, Polyethylene Glycol

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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