Fabrication of Bioceramic Scaffolds for Tissue Engineering Using Additive Manufacturing Technology

Abstract:

In this paper, the hydroxyapatite (HA) based bioceramic materials were used in a rapid prototyping (RP) system to fabrication bioceramic bone scaffold for tissue engineering (TE) using an additive manufacturing (AM) technology. When the bioceramic slurry is sintered via the processing parameters of an 85 mm/s laser scanning speed, 24.5 W of laser power, 10 kHz of scanning frequency, and 2500 Cp of slurry viscosity, a porous bone scaffold can be fabricated under a lower laser power energy. Results indicate that the bending strength of the scaffold was 14.2 MPa, which could be improved by heat-treatment at 1200 °C for 2 hour. MTT method and SEM observations confirmed that the fabricated bone scaffolds possess suitable biocompatibility and mechanical properties, allowing smooth adhesion and proliferation of osteoblast-like cells. Therefore, the fabricated bone scaffolds have great potential for development in tissue engineering.

• Periodical: Advanced Materials Research (Volumes 706-708)
• Pages: 118-121
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.706-708.118
• Online since: June 2013
• Authors: Fwu Hsing Liu, Wen Hsueng Lin, Ruey Tsung Lee, Hsiu Ping Wang, Hsiu Ling Hsu
• Keywords: Bioceramic, Laser Sintering, Rapid Prototyping (RP), Scaffold, Tissue Engineering

References

[1] J. Wei, Y.B. Li and Y. He: J Mater Sci Lett Vol.403 (2005), pp.793-797

[2] C.P. Jiang, J.R Huang and M.F. Hsieh: Rapid Prototyping J Vol.17 (2011), pp.288-297

[3] C.C. Kuo: Mater and Manuf Processes Vol.27 (2012), pp.383-388

[4] Y.L. Cheng and M.L. Lee: Rapid Prototyping J Vol.15 (2009), pp.29-41

[5] H.C. Yen: J Euro Ceram Soc Vol.32 (2012), pp.3123-3128

[6] S.F. Hulbert: Ceramics in Clinical Application Vol.4 (1987), pp.3-27

[7] F.H. Liu: J Sol-Gel sci. and tech Vol.64 (2012), pp.704-710

[8] F.H. Liu: Ceram Int Vol.37 (2011), pp.2789-2794

[9] F.H. Liu and Y.S. Liao: J Euro Ceram Soc Vol.30 (2010), pp.3283-3289

[10] J. Zeltinger: Tissue Eng Vol.7 (2001), pp.557-572

[11] T.H. Ang: Mater sci Eng: C Vol.20 (2002), pp.35-42

[12] B. Ma: Manufacturing and management Vol.207 (2006), pp.710-716

[13] D.D. Deligianni, N.D. Katsala and Y.F. Missirlis: Biomaterials Vol.22 (2001), pp.87-96

[14] F.H. Liu, Y.K. Shen and J.L. Lee: Int J Precis Eng Manuf Vol.13 (2012), pp.439-444