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Drug Release from a pH/Temperature Sensitive Hydrogel Bead of Poly(Lysine Methyl Ester-Diacetoxy Tartaric Acid) and Sodium Alginate

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Abstract:

In this study, a pH/temperature sensitive polymeric hydrogel from poly (lysine methyl ester-diacetoxy tartaric acid) and sodium alginate (PLMD-SA) was prepared via the condensation polymerization. Using indomethacin as the model drug, the controlled drug-release from the resulting pH/temperature sensitive PLMD-SA was evaluated as functions of pH, PLMD content and temperature by UV spectrophotometer. It was found that the release amount of indomethacin in pH=7.4 phosphate buffer solution (PBS) was evidently higher than in pH=2.3 PBS.

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Periodical:

Advanced Materials Research (Volume 711)

Pages:

14-17

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.711.14

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Online since:

June 2013

Authors:

Kui Lin Deng, Hui Juan Shen, Shu Liang Wang, Meng Wang, Xin Ma, Xue Ying Fan, Wen Hui Jin, Chun Xiu Li

Keywords:

Drug Release, pH/temperature Sensitive, Poly(Lysine Methyl Ester-Diacetoxy Tartaric Acid)

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