Perfluoroalkylated-Pyridine Catalyzed the Mannich-Type Reaction: An Example on Elimination the Fluorous Solvent Requirement for Fluorous Catalysis

Abstract:

The three-component Mannich-type reactions of different ketones with various aromatic aldehydes and aromatic amines proceeds efficiently in the presence of catalytic amount of perfluoroalkylated-pyridine in a fluorous biphasic system without fluorous solvent, which has prompted various concerns involving cost, solvent leaching, and environmental persistence. The reactions give various β-arylamino ketones in good to excellent yield. The catalyst can be recovered by simple cooling and precipitation and used again.

• Periodical: Advanced Materials Research (Volumes 726-731)
• Pages: 165-170
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.726-731.165
• Online since: August 2013
• Authors: Wen Bin Yi, Chun Cai
• Keywords: Fluorous Biphasic Catalysis, Fluorous-Solvent-Free, Mannich-Type Reaction, Perfluoroalkylated-Pyridine

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