Photothermal Imaging (PTI) System for the Imaging of Gold Nano-Particles and Cellular Organelles
Photo-thermal imaging (PTI) is an imaging technique that can provide a resolution exceeding the diffraction limit. The theoretical resolution limit is less than 1 nm, therefore it is particularly suited to analyse particles in nano-size targets. It is also a non-labelling, high temporal resolution technique that can be conducted in a normal live cell environment. In this paper, a PT imaging microscopy system has been demonstrated and the integrity of the system is verified through a series of experiments on different samples, including red polystyrene bead and carbon nano-tube. The PTI technique can find further applications in biology studies for the visualization of cell organelles and apoptosis studies.
Selin Teo, A. Q. Liu, H. Li and B. Tarik
C. L. Wong et al., "Photothermal Imaging (PTI) System for the Imaging of Gold Nano-Particles and Cellular Organelles", Advanced Materials Research, Vol. 74, pp. 45-48, 2009