Study on Synthesis and Performance of Collagen-Modified Polylactide

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In this paper, collagen modified polylactide (CPLA) was synthesized by means of graft modification, and its structure was confirmed by FTIR and FITC-labeled fluorescence spectra. The performance of CPLA was characterized with hydrophilicity test and degradability test. The results showed that collagen had successfully grafted on the polylactide (PLA) and the graft ratio of collagen on CPLA was about 5%. The water absorotion of CPLA was significantly higher than PLA and its hydrophilicity was better than PLA. Moreover, there was no obvious acid-catalyzed self-accelerating degradation behavior in the degradation process of CPLA. The results suggested that CPLA showed a great potential as particles for drug delivery.

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223-226

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September 2013

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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