Microwave-Assisted Parallel Synthesis and Antioxidant Activity of Aryloxy-Acetyl Ferrocenes Derivatives

Wen Bin Wang; Dan Liu; Dan Wei Pi; Quan Bin Liao; Ming Guo Liu

doi:10.4028/www.scientific.net/AMR.781-784.1085

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 781-784Microwave-Assisted Parallel Synthesis and...

Microwave-Assisted Parallel Synthesis and Antioxidant Activity of Aryloxy-Acetyl Ferrocenes Derivatives

Abstract:

Seven novel aryloxy-acetyl ferrocene derivatives were parallel synthesized under microwave irradiation conditions from chloroacetyl ferrocenes and substituted phenols with the aim of obtaining potential antioxidant agents. The target compounds were identified by IR, ¹H NMR, MS and elemental analysis, and their antioxidant assays indicated that all the aryloxy-acetyl ferrocenes had certain effect on eliminating 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. Their antioxidation activity significantly improved when rising the temperature until the temperature was 35°C. The structure-activity relationship analysis showed the electron-donating substituted aryloxyl group could strengthen the radical scavenging abilities, while the electron-withdrawing effects would block antioxidant abilities.

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Periodical:

Advanced Materials Research (Volumes 781-784)

Pages:

1085-1088

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.781-784.1085

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Online since:

September 2013

Authors:

Wen Bin Wang, Dan Liu, Dan Wei Pi, Quan Bin Liao, Ming Guo Liu

Keywords:

Antioxidant Activity, Aryloxy-Acetyl Ferrocene, Microwave Irradiation, Parallel Synthesis, Structure Characterization

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