Synthesis, Structure and Gastric H+/K+-ATPase Inhibitory Activities of Bisabolonalone Hydrazone Carboxamides

Lei Jin; Lei Chen; Hua Jun Luo; Zhi Yong Guo; Nian Yu Huang; Wei Qiao Deng

doi:10.4028/www.scientific.net/AMR.781-784.1098

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 781-784Synthesis, Structure and Gastric H+/K+-ATPase...

Synthesis, Structure and Gastric H⁺/K⁺-ATPase Inhibitory Activities of Bisabolonalone Hydrazone Carboxamides

Abstract:

Five novel bisabolonalone hydrazone carboxamides were synthesized as potential anti-ulcer agents. Their structures were characterized by NMR, IR and ESI-MS. All of the compounds possessed the better H⁺/K⁺-ATPase inhibitory activity than the commercial omeprazole with the IC₅₀ of 18~68 μM in vitro. These compounds could be potentially use for the treatment of ulcer related diseases.

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Periodical:

Advanced Materials Research (Volumes 781-784)

Pages:

1098-1101

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https://doi.org/10.4028/www.scientific.net/AMR.781-784.1098

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Online since:

September 2013

Authors:

Lei Jin, Lei Chen, Hua Jun Luo, Zhi Yong Guo, Nian Yu Huang, Wei Qiao Deng

Keywords:

Bisabolangelone, H⁺/K⁺-ATPase Inhibitor, Hydrazone Carboxamide, Synthesis

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