A Novel Platinum Complex as Telomeric G-Quadruplex Binders

Xu Jian Luo; Qi Pin Qin; Yu Lan Li; Yan Cheng Liu

doi:10.4028/www.scientific.net/AMR.781-784.1111

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 781-784A Novel Platinum Complex as Telomeric G-Quadruplex...

A Novel Platinum Complex as Telomeric G-Quadruplex Binders

Abstract:

A new platinum (II) complex has been synthesized and characterized by IR, NMR, ESI-MS and element analysis. The affinities of the complex toward telomeric G-quadruplex DNA [Htel-21] has been investigated by CD, UVVis. The results revealed that the complex can induce and stabilizes the antiparallel telomeric G-quadruplex DNA, and bind very strongly to G-quadruplex DNA. The inhibition ratio of the complex was screened against four cancer cell lines in comparison to cisplatin and it showed a higher activity than cisplatin.

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Periodical:

Advanced Materials Research (Volumes 781-784)

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1111-1114

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.781-784.1111

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Online since:

September 2013

Authors:

Xu Jian Luo*, Qi Pin Qin, Yu Lan Li, Yan Cheng Liu

Keywords:

G-Quadruplex, Inhibition Ratio, Platinum Complex, Telomeric DNA

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