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Anticancer Activity of Platinum (II) Complex as G-Quadruplex DNA Binders

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Abstract:

A platinum (II) complex has been synthesized and characterized. The complex binding properties with G-quadruplex DNA and ds26 were examined by FID and CD spectroscopic methods. The results revealed that the platinum (II) complex can induce the antiparallel G-quadruplex structure of HTG21 conformation in the absence of added K+ with selectivity over other G-quadruplex DNA and duplex DNA. The cytotoxicity of the platinum (II) was screened against four cancer cell lines and normal cells of HL-7702 in comparison to cisplatin and it showed a higher activity than cisplatin, with inhibition rates ranging from (40.06±1.65)% to (89.47±1.14)%. Furthermore, the platinum (II) complex displayed lower cytotoxic activities to HL-7702 (normal cell) compared with the cancer cell lines.

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Periodical:

Advanced Materials Research (Volumes 781-784)

Pages:

1130-1133

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.781-784.1130

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Online since:

September 2013

Authors:

Qi Pin Qin, Yu Lan Li, Yan Cheng Liu, Xu Jian Luo

Keywords:

Cytotoxicity, G-Quadruplex DNA, Interaction, Platinum (II) Complex

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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