Synthesis and In Vitro Anti-Ulcer Effect of Bisabolangelone Oxime Ether Derivatives

Fang Fang Wu; Yu Rong Song; Jiao Yu Zhang; Lei Chen; Jun Zhi Wang

doi:10.4028/www.scientific.net/AMR.781-784.1122

Paper Titles

Optimization of Enzymatic Reaction Conditions of γ-Cyclomaltodextrin by CGTase
p.1102

Anticancer Activity of Novel Platinum Complex as DNA Binders
p.1107

A Novel Platinum Complex as Telomeric G-Quadruplex Binders
p.1111

The Relationship of Flowability, Hygroscopicity and Compressibility Properties between Microcrystalline Cellulose, Sarcandrae Extract Powder, and the Mixture of the Two Materials
p.1115

Synthesis and In Vitro Anti-Ulcer Effect of Bisabolangelone Oxime Ether Derivatives
p.1122

The Semi-Synthesis and Cytotoxic Activity of Trametenolic Acid B Derivatives
p.1126

Anticancer Activity of Platinum (II) Complex as G-Quadruplex DNA Binders
p.1130

Studies on the Chemical Constituents of Fritillaria monanth
p.1134

Researches on the Structure and Antioxidant Activity of Apigenin-La (III) Complex
p.1138

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 781-784Synthesis and In Vitro Anti-Ulcer Effect of...

Synthesis and In Vitro Anti-Ulcer Effect of Bisabolangelone Oxime Ether Derivatives

Abstract:

Four bisabolangelone oxime ether derivatives were synthesized and separated as potential anti-ulcer agents. Their structures were characterized by NMR, IR and ESI-MS. Preliminarily H⁺/K⁺-ATPase activity evaluation indicated that all the target oxime ethers exhibited the better H⁺/K⁺-ATPase inhibitory activities than the commercial omeprazole with the IC₅₀ of 17~46 μM. These compounds might be used as potential anti-ulcer agents in the treatment of acid-related diseases.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Advanced Materials Research (Volumes 781-784)

Pages:

1122-1125

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.781-784.1122

Citation:

Cite this paper

Online since:

September 2013

Authors:

Fang Fang Wu*, Yu Rong Song, Jiao Yu Zhang, Lei Chen, Jun Zhi Wang

Keywords:

Bisabolangelone, H⁺/K⁺-ATPase Inhibitory Activity, Oxime Ether, Synthesis

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

* - Corresponding Author

References

[1] M. Suzuki, H. Suzuki and T. Hibi: J. Clin. Biochem. Nutr. Vol. 42 (2008), p.71.

Google Scholar

[2] G. Sachs, H.H. Chang, E. Rabon, R. Schackman, M. Lewin, G. Saccomani: J. Biol. Chem. Vol. 251 (1976), p.7690.

Google Scholar

[3] J.M. Shin, K. Munson, O. Vagin and G. Sachs: Eur. J. Physiol. Vol. 457 (2009), p.609.

Google Scholar

[4] Z. Fang and Z. Liao: The Medicinal Plants from Enshi of Hubei (The Science and Technological Press of Hubei, Wuhan, 2006).

Google Scholar

[5] S. Fu: Hubei Herbal (3) (The Science and Technological Press of Hubei, Wuhan, 2002).

Google Scholar

[6] Y.J. Ahn, S.U. Kang, H.G. Kim, S.I. Kim, J.R. Kim, I.H. Jung, Y.E. Na and B.S. Kim, K.R. Patent 2008011958. (2008).

Google Scholar

[7] J.Z. Wang, L.B. Zhu, K. Zou, F. Cheng, F.J. Dan, Z.Y. Guo, Z.J. Cai,; J. Yang: J. Ethnopharmacol. Vol. 123 (2009), p.343.

Google Scholar

[8] A. Lansiaux, L. Dassonneville, M. Facompré, A. Kumar, C.E. Stephens, M. Bajic, F. Tanious, W.D. Wilson, D.W. Boykin and C. Bailly: J. Med. Chem. Vol. 45 (2002), p. (1994).

DOI: 10.1021/jm010539n

Google Scholar

[9] A.Y. Sukhorukov and S. L. Ioffe: Chem. Rev. Vol. 111 (2011), p.5004.

Google Scholar

[10] N. Huang, L. Chen, Z. Liao, H. Fang, J. Wang and K. Zou: Chin. J. Chem. Vol. 30 (2012), p.71.

Google Scholar