Anticancer Activity of Novel Platinum Complex as DNA Binders

Xu Jian Luo; Qi Pin Qin; Yu Lan Li; Yan Cheng Liu

doi:10.4028/www.scientific.net/AMR.781-784.1107

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 781-784Anticancer Activity of Novel Platinum Complex as...

Anticancer Activity of Novel Platinum Complex as DNA Binders

Abstract:

A new phenanthroimidazole platinum (II) complex has been synthesized and characterized by IR, NMR, ESI-MS, element analysis. The affinities of the complex toward ct-DNA was determined by circular dichroism absorption (CD), UV-Vis absorption. Results indicate that the complex interact with ct-DNA by classical intercalating mode. The cytotoxicities of the complex was screened against four cancer cell lines and normal cells of HL-7702 in comparison to cisplatin and it showed a higher activity than cisplatin, with IC₅₀ values in the range 8.7417.11 μmol/L. Furthermore, the complex displayed lower cytotoxic activities to HL-7702 (normal cell) compared with the cancer cell lines.

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Periodical:

Advanced Materials Research (Volumes 781-784)

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1107-1110

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https://doi.org/10.4028/www.scientific.net/AMR.781-784.1107

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Online since:

September 2013

Authors:

Xu Jian Luo, Qi Pin Qin, Yu Lan Li, Yan Cheng Liu

Keywords:

Cytotoxicity, DNA, Interaction, Platinum Complex

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References

[1] T.C. Jenkins. Curr. Med. Chem. 7 (2000): 99.

Google Scholar

[2] R. Kieltyka, J. Fakhoury, N. Moitessier, H.F. Sleiman. Chem. Eur. J. 14 (2008): 1145.

Google Scholar

[3] H1 NMR(500 MHz, [D6] DMSO): d = 8. 62(d, 1H); 8. 16(d, 2H); 8. 12 (d, 2H); 7. 46(dd, 2H); 7. 03 (d, 2H); 2. 67(m, 6H); 2. 92(br s, 4H) ppm. C13 NMR(125 MHz, [D6] DMSO): d = 39. 29, 112. 28, 123. 54, 123. 66, 123. 96, 127. 89, 128. 03, 132. 88, 132. 95, 136. 32, 136. 47, 140. 79, 140. 91, 145. 75, 151. 22; ESI-MS m/z: 587. 1 [M-Cl]+, 551. 2 [M-2Cl-H]+, Anal. Calc. (for C20H19Cl2N7Pt) C 38. 53; H 3. 07; N 15. 73 % , Found. C 38. 03; H 2. 89; N 15. 14.

Google Scholar

[4] D.L. Ma, C.M. Che. Chem. Eur. J. 9 (2003): 6133.

Google Scholar

[5] H. Ihmels, B.B. Engels, K. Faulhaber, D.C. Lennartz, Chem. Eur. J. 6 (2000): 2854.

Google Scholar

[6] H. Chao, W.J. Mei, Q.W. Huang, L.N. Ji. J. Inorg. Biochem. 92 (2002): 165.

Google Scholar

[7] P.F. Shi, Q. Jiang, Y.M. Zhao, Y.M. Zhang, J. Lin, L.P. Lin, J. Ding, Z.J. Guo. J. Biol. Inorg. Chem. 11 (2006): 745.

Google Scholar

[8] X. Li, Y. Peng, J.S. Ren, X.G. Qu. Biochemistry, 45 (2006): 13543.

Google Scholar

[9] T. Mosmann. J. Immunol. Methods. 65 (1983): 55.

Google Scholar