Synthesis and Interleukin-6 Inhibitory Activities of 3-Alkyloxylindolizine Derivatives

Abstract:

The synthesis and interleukin-6 (IL-6) inhibitory activities for a series of 3-alkyloxylindolizine derivatives were described. The target products were characterized by NMR, IR, ESI-MS and elemental analysis, and two compounds revealed better IL-6 inhibitory effects on LPS-induced IL-6 expression in mouse macrophages with the corresponding inhibition ratio of 66% and 74% at 100 μM. The bioactive compounds might be a good generation for further optimization as potential anti-inflammatory agents.

• Periodical: Advanced Materials Research (Volumes 781-784)
• Pages: 1089-1092
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.781-784.1089
• Online since: September 2013
• Authors: Cheng Qiao Cao, Yong Wei, Kun Zou, Jian Feng Chen, Nian Yu Huang*
• Keywords: 3-alkyloxylindolizine, Anti-Inflammatory Agents, IL-6 Inhibitors, Synthesis

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