Synthesis and Anti-Inflammatory Activity of 3-Aryloxylindolizine Derivatives via Sonogashira Coupling/5-endo-trig Cycloisomerization Domino Strategy

Yong Wei; Cheng Qiao Cao; Jian Feng Chen; Kun Zou; Zhang Shuang Deng; Nian Yu Huang

doi:10.4028/www.scientific.net/AMR.781-784.1093

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 781-784Synthesis and Anti-Inflammatory Activity of...

Synthesis and Anti-Inflammatory Activity of 3-Aryloxylindolizine Derivatives via Sonogashira Coupling/5-endo-trig Cycloisomerization Domino Strategy

Abstract:

With the aim of obtaining potential IL-6 inhibitor for the treatment of rheumatoid arthritis, four 3-aryloxylindolizine derivatives were synthesized from the 2-bromopyridine and aryl propargyl ether through the Sonogashira coupling/5-endo-trig cycloisomerization domino strategy. These compounds were characterized by NMR, IR, EI-MS and elemental analysis. Their biological activities were evaluated by the bacterial lipopolysaccharide (LPS) stimulation of mouse cells on the RAW264.7 inflammation model. All the compounds revealed good anti-inflammatory activities with the inhibitions of 71~82% against IL-6 at 100 μM. The bioactive 3-aryloxylindolizines might be used as potential anti-inflammatory drugs.

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Periodical:

Advanced Materials Research (Volumes 781-784)

Pages:

1093-1097

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.781-784.1093

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Online since:

September 2013

Authors:

Yong Wei, Cheng Qiao Cao, Jian Feng Chen, Kun Zou, Zhang Shuang Deng, Nian Yu Huang*

Keywords:

3-aryloxylindolizine, 5-endo-trig, Anti-Inflammatory Agents, IL-6 Inhibitory Effect, Synthesis

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