The Relationship of Flowability, Hygroscopicity and Compressibility Properties between Microcrystalline Cellulose, Sarcandrae Extract Powder, and the Mixture of the Two Materials

Zheng Gen Liao; Jie Wang; Xin Li Liang; Nan Zhang; Shao Jin Zhong; Liang Shan Ming; Guo Wei Zhao; Yun Luo

doi:10.4028/www.scientific.net/AMR.781-784.1115

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 781-784The Relationship of Flowability, Hygroscopicity...

The Relationship of Flowability, Hygroscopicity and Compressibility Properties between Microcrystalline Cellulose, Sarcandrae Extract Powder, and the Mixture of the Two Materials

Abstract:

Microcrystalline Cellulose and Sarcandrae extract powder were used to study the relationships of pharmaceutical properties of powders before and after mixing operation. The theoretical values of the physical quantities of the binary mixture were calculated based on the random mixing theory. The measured values of angle of repose, hygroscopicity of binary mixture were larger than that of theoretical calculations. The effective Kawakita a and b for the MCC had changed by mixing operation. The parameters of blend powder reduced compared with MCC except D-1. The results suggested that the mixing behavior was not a complete random or simple superposition operation for the rough and sticky particles. The mixing process would create novel particles and the physical quantities of novel particles would changes regularly.

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Periodical:

Advanced Materials Research (Volumes 781-784)

Pages:

1115-1121

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.781-784.1115

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Online since:

September 2013

Authors:

Zheng Gen Liao, Jie Wang*, Xin Li Liang, Nan Zhang, Shao Jin Zhong, Liang Shan Ming, Guo Wei Zhao, Yun Luo

Keywords:

Microcrystalline Cellulose, Mixing Operation, Novel Particle, Pharmaceutics Properties, Sarcandrae Extract Powder, Theoretical Value

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