The Semi-Synthesis and Cytotoxic Activity of Trametenolic Acid B Derivatives

Qiao Yin Zhang; Ming Ruo Ding; Wei Chen Zhai; Yuan Yao; Yan Mei Zhou; Jun Zhi Wang

doi:10.4028/www.scientific.net/AMR.781-784.1126

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 781-784The Semi-Synthesis and Cytotoxic Activity of...

The Semi-Synthesis and Cytotoxic Activity of Trametenolic Acid B Derivatives

Abstract:

The trametenolic acid B was a bioactive lanostane-type triterpenoid in Trametes lactinea (Berk.) Pat with. Five novel trametenolic acid B derivatives were synthesized, characterized and evaluated the cytotoxicity against MDA-MB-231 cells with the aim of obtaining better anti-tumtor agents. The compound IV exhibited significantly cytotoxicity activities with IC₅₀ value of 22.39 μM.

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Periodical:

Advanced Materials Research (Volumes 781-784)

Pages:

1126-1129

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.781-784.1126

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Online since:

September 2013

Authors:

Qiao Yin Zhang, Ming Ruo Ding, Wei Chen Zhai, Yuan Yao, Yan Mei Zhou, Jun Zhi Wang*

Keywords:

Breast Cancer MDA-MB-231 Cells, Cytotoxic Activity, Semi-Synthesis, Trametenolic Acid B, Triterpenoid

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* - Corresponding Author

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