Effect of Plant Compound Curcumin on the Expression of a-Synuclein in Hippocampal Neurons of APPswe/PS1dE9 Double Transgenic Mice

Abstract:

In this study, we aim to investigate the effect of curcumin on the expression of a-synuclein in the APPswe/PS1dE9 double transgenic mice. APPswe/PS1dE9 double transgenic mice were used as AD (Alzheimer's disease) model and fed with different concentrations of curcumin every day for 6 months, then immunohistochemistry method were used to detect the expression of a-synuclein in hippocampus of mice. The expression of a-syn in hippocampal neuron was decreased significantly after treated with 0.16g/kg to 1.0g/kg curcumin, the change was apparent in dose-dependent manner (P<0.05). a-synuclein pay an important role in the genesis and development of Alzheimer's disease and decreased level of a-synuclein might contribute to the neuroprotective effect of Curcumin, which may become a new target for the prevention and treatment of Alzheimer's disease.

• Periodical: Advanced Materials Research (Volumes 781-784)
• Pages: 643-646
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.781-784.643
• Online since: September 2013
• Authors: Xiao Lin, Li Yu
• Keywords: Alzheimer's Disease, A-Synuclein, Curcumin, Transgenic Mice

References

[1] Tu CT, Han B, Yao QY, et al: Int Immunopharmacol. Vol. 12 (2012), p.151.

[2] Fernanda G De Felice, Marcelo N N Vieira, Theresa R Bomfim, et al: Proc Natl Acad Sci USA. Vol. 106 (2009), p. (1971).

[3] Iwai A, Masliah E, Yoshimoto M, et al: Neuron. Vol. 14 (1995), p.467.

[4] Hwang H, Choi H, Kim HK, et al: Anal Biochem. Vol. 386 (2009), p.293.

[5] Oddo S, Vasilevko V, Caccame A, et al: J Biol Chem. Vol. 281(2006), p.39413.

[6] Duka T, Sidhu A: Neurotox Res. Vol. 10 (2006), p.1.

[7] Liu G W, Zhang CY, Yin J J, et al: Neurosci Lett. Vol. 454 (2009), p.187.

[8] Devi L, Raghavendran V, Prabhu B M, et al: J Biol Chem. Vol. 283 (2008), p.9089.

[9] Madine J, Doig AJ, Middleton DA: J Am Chem Soc. Vol. 130 (2008), p.7873.

[10] Zhang L, Fiala M, Cashman J, et al: J Alzheimers Dis. Vol. 10 (2006), p.1.

[11] Pandey N, Strider J, Nolan WC, et al: Acta Neuropathol. Vol. 115 (2008), p.479.

[12] Dobson CM: Semin Cell Dev Biol. Vol. 15 (2004), p.3.