Study of AMP-Activated Protein Kinase Agonists by Structure-Based Drug Designing

Abstract:

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AMP-activated protein kinase (AMPK) is a metabolite- sensed protein kinase in various eukaryotes. The activated AMPK regulates important proteins which cause diabetes, obesity, metabolic aberrant, and also breast cancer. In this study, the yeast AMPK structure was used as a template to model the human AMPK structure. By homology modeling, the reliable AMPK structure was built, and the active binding site was defined corresponding to X-ray crystal structure of yeast AMPK By virtual screening the database., All the potent ligands had the H-bond interaction in the key residues, same as the control. Thus, we suggested the phenylamide derivates might be the potent AMPK agonists.

Info:

Periodical:

Advanced Materials Research (Volumes 79-82)

Edited by:

Yansheng Yin and Xin Wang

Pages:

2187-2190

DOI:

10.4028/www.scientific.net/AMR.79-82.2187

Citation:

Y. H. Chang et al., "Study of AMP-Activated Protein Kinase Agonists by Structure-Based Drug Designing", Advanced Materials Research, Vols. 79-82, pp. 2187-2190, 2009

Online since:

August 2009

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Price:

$35.00

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