Paper Titles
The Effect of Excess Silane-69 Used for Surface Modification on Cure Characteristic and Mechanical Properties of Precipitated Silica Filled Natural Rubber (PSi/NR)
p.2171
Influence of Curing Process on the Performance of Epoxy Thermosets
p.2175
Research on the Antifouling Mechanisms of Copper and its Alloys
p.2179
The Effect of Second Filler on Cure Characteristic and Mechanical Properties of Si-69 Treated Precipitate Silica/NR Composite
p.2183
Study of AMP-Activated Protein Kinase Agonists by Structure-Based Drug Designing
p.2187
Behavior of Heavy Plastic Deformation of Cu-15Cr-0.1Zr In Situ Composite
p.2191
Effect of Electrode Shape on Power and Internal Resistance in Benthic Microbial Fuel Cell Material on Marine Sediment
p.2195
Tribological Characteristics of Surface Treatment for Piston Pin
p.2199
Synthesis of Crosslinkable Core-Shell Emulsion and Rheology of the Core-Shell/Amine Crosslinking Process
p.2203

Study of AMP-Activated Protein Kinase Agonists by Structure-Based Drug Designing

Article Preview

Abstract:

AMP-activated protein kinase (AMPK) is a metabolite- sensed protein kinase in various eukaryotes. The activated AMPK regulates important proteins which cause diabetes, obesity, metabolic aberrant, and also breast cancer. In this study, the yeast AMPK structure was used as a template to model the human AMPK structure. By homology modeling, the reliable AMPK structure was built, and the active binding site was defined corresponding to X-ray crystal structure of yeast AMPK By virtual screening the database., All the potent ligands had the H-bond interaction in the key residues, same as the control. Thus, we suggested the phenylamide derivates might be the potent AMPK agonists.

You might also be interested in these eBooks
Multi-Functional Materials and Structures II View Preview

Info:

Periodical:

Advanced Materials Research (Volumes 79-82)

Pages:

2187-2190

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.79-82.2187

Citation:

Cite this paper

Online since:

August 2009

Authors:

Yea Huey Chang, Tin Yun Ho, Chieh Hsi Wu, Chien Yu Chen, Hung Jin Huang, Fuu Jen Tsai, Chang Hai Tsai, Calvin Yu Chian Chen

Keywords:

Activated Protein Kinase (AMP), Docking, Molecular Simulation, QSAR

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

© 2009 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

References

[1] J.M. Corton, J.G. Gillespie, S.A. Hawley and D.G. Hardie: Eur. J. Biochem. Vol. 229 (1995), p.558.

Google Scholar

[2] D. Carling, V.A. Zammit and D.G. Hardie: FEBS Lett. Vol. 223 (1987), p.217.

Google Scholar

[3] S.P. Davies, S.A. Hawley, A. Woods, D. Carling, T.A. Haystead and D.G. Hardie: Eur. J. Biochem. Vol. 223 (1994), p.351.

Google Scholar

[4] J.R. Dyck, G. Gao, J. Widmer, D. Stapleton, C.S. Fernandez, B.E. Kemp and L.A. Witters: J. Biol. Chem. Vol. 271 (1996), p.17798.

Google Scholar

[5] R. Jiang and M. Carlson: Mol. Cell. Biol. Vol. 17 (1997), p. (2099).

Google Scholar

[6] U. Riek, R. Scholz, P. Konarev, A. Rufer, M. Suter, A. Nazabal, P. Ringler, M. Chami, S.A. Muller, D. Neumann, M. Forstner, M. Hennig, R. Zenobi, A. Engel, D. Svergun, U. Schlattner and T.: J. Biol. Chem. Vol. 283 (2008), p.18.

DOI: 10.1074/jbc.m708379200

Google Scholar