Cinchona Alkaloid-Silyl Ether Derivatives as Organocatalysts for Asymmetric “Interrupted” Feist-Bénary Reaction

Ying Jin; Sheng Chang; Tian Yi Zhang; Bo Feng

doi:10.4028/www.scientific.net/AMR.864-867.456

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 864-867Cinchona Alkaloid-Silyl Ether Derivatives as...

Cinchona Alkaloid-Silyl Ether Derivatives as Organocatalysts for Asymmetric “Interrupted” Feist-Bénary Reaction

Abstract:

Four cinchona alkaloid-silyl ether derivatives have been used to catalyze the asymmetric “interrupted” Feist-Bénary reaction of ethyl bromopyruvate/substituted bromo-ketoesters and 1,3-Cyclohexadione. The corresponding hydroxydihydrofurans have been obtained in excellent yields (85-96%) with high enantiomeric excess (ee) values of up to 90%.

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Periodical:

Advanced Materials Research (Volumes 864-867)

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456-459

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.864-867.456

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Online since:

December 2013

Authors:

Ying Jin, Sheng Chang, Tian Yi Zhang, Bo Feng*

Keywords:

Asymmetric, Cinchona Alkaloid-Silyl Ethers, Furan, Interrupted Feist-Bénary Reaction

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* - Corresponding Author

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