Northeast Chinese Herbs against Pulmonary Fibrosis Screening Experiment

Nan Shen; Zhi Wei Li; Ying An; Xue Chen; Bo Xu; Li Jing Zhao; Jun Tao Lei

doi:10.4028/www.scientific.net/AMR.864-867.472

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 864-867Northeast Chinese Herbs against Pulmonary Fibrosis...

Northeast Chinese Herbs against Pulmonary Fibrosis Screening Experiment

Abstract:

Objective:To screen the Chinese herbal medicine with anti-pulmonary fibrosis, to provide reference for further study on anti-drug pulmonary fibrosis. Methods By complement lysis test, oleinic acid model of rats and paraquat model of mice were made as pulmonary fibrosis animal model to screen the medicine activity. Results in vitro, Cangzhu and Tinglizi had great significance in inhibition of RBC hemolysis; in vivo, compared with Control group, Hyp content of lung tissues in animal model groups had statistical significance; compared with model group, Hyp content of therapy groups had statistical significance, pathological lesion was reduced. Conclusion Extracts of Cangzhu and Tinglizi has certain resistance to pulmonary fibrosis activity.

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Periodical:

Advanced Materials Research (Volumes 864-867)

Pages:

472-476

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.864-867.472

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Online since:

December 2013

Authors:

Nan Shen, Zhi Wei Li, Ying An, Xue Chen, Bo Xu, Li Jing Zhao, Jun Tao Lei

Keywords:

Pulmonary Fibrosis, Screen, Traditional Chinese Medicine

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References

[1] Kim DS. Acute exacerbations in patients with idiopathic pulmonary fibrosis. [J] Respir Res. 2013 Aug 21; 14(1): 86.

Google Scholar

[2] Li LR, Sydenham E, Chaudhary B, et al. Glucocorticoid with cyclophosphamide for paraquat-induced lung fibrosis. . [J] Cochrane Database Syst Rev. 2012 Jul 11; 7: CD008084.

DOI: 10.1002/14651858.cd008084.pub3

Google Scholar

[3] Ding NH, Li JJ, Sun LQ. Molecular Mechanisms and Treatment of Radiation-Induced Lung Fibrosis. [J]Curr Drug Targets. 2013 , 31. 205-209.

Google Scholar

[4] He C, Ryan AJ, Murthy S, et al. Accelerated Development of Pulmonary Fibrosis via Cu, Zn-superoxide Dismutase-induced Alternative Activation of Macrophages [J]. Biol Chem. 2013 Jul 12; 288(28): 20745-20757.

DOI: 10.1074/jbc.m112.410720

Google Scholar

[5] Harris WT, Kelly DR, Zhou Y, et al. Myofibroblast differentiation and enhanced tgf-B signaling in cystic fibrosis lung disease. [J]PLoS One. 2013 , 8(8): e70196.

DOI: 10.1371/journal.pone.0070196

Google Scholar

[6] Maitra M, Dey M, Yuan WC, et al. Lung Fibrosis Associated Surfactant Protein A1 and C Variants Induce Latent TGF-β1 Secretion in Lung Epithelial Cells. J Biol Chem. 2013, 7. 1703-1710.

DOI: 10.1074/jbc.m113.475335

Google Scholar

[7] Jones HA, Schofield JB, Krausz T, at al. Pulmonary fibrosis correlates with duration of tissue neutrophil activation. [J]Am J Respir Crit Care Med. 1998 , 158(2): 620-628.

DOI: 10.1164/ajrccm.158.2.9711075

Google Scholar