Drug Delivery System of a Radio-Protective Inclusion Complex

Lothar A. Heinrich; Betina Pajaziti; Rakhimdzhan Roziev

doi:10.4028/www.scientific.net/AMR.872.231

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Deposition of Biocompatible Coatings from the Ablation Plasma Produced by the Irradiation of the Hydroxyapatite Target with Powerful Ion Beams
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Drug Delivery System of a Radio-Protective Inclusion Complex
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Effect of Humic Substances and Silicon Ions on Stability of Iron Hydroxide (III) Nanoparticles
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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 872Drug Delivery System of a Radio-Protective...

Drug Delivery System of a Radio-Protective Inclusion Complex

Abstract:

The novel radio-protective drug 9-phenyl symm octahydro selenoxanthene is insoluble in water. The complexation with hydroxypropyl beta-cyclodextrin increases the water solubility improving the bioavailability. The stoichiometry of the supramolecular host-guest complex was studied by displacement experiments using fluorescence spectroscopy. With respect to the application in the radiologic brachy therapy the inclusion complex was encapsulated by spray drying with both, poly D,L-lactic-co-glycolic acid and gelatin. The in-vitro irradiation tests of the final ointment formulation show the inhibition of neoplasm development, and an efficient protection effect against radiation.

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Periodical:

Advanced Materials Research (Volume 872)

Pages:

231-236

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.872.231

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Online since:

December 2013

Authors:

Lothar A. Heinrich, Betina Pajaziti, Rakhimdzhan Roziev

Keywords:

Brachy Therapy, Cyclodextrin, Encapsulation, Inclusion Complex, Radiation Therapy (RT), Radio-Protective Drug-Delivery

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