Saponins from Panax japonicas Reduces Myocardial Infarction Induced Reactive Oxygen Species Production and Cardiomyocyte Apoptosis via Activation of the Nrf-2 Pathway

Abstract:

Myocardial infarction (MI) increased reactive oxygen species (ROS) and cardiomyocyte apoptosis. Saponins from Panax japonicus (SPJ) exerted beneficially cardioprotective effects on myocardial ischemia injury and possess antioxidant properties to scavenge the toxic radicals. Nuclear factor erythroid 2-related factor (Nrf2) is a transcription factor that controls the expression of a large pool of anti-oxidant and protects cells from oxidative damage. The data from this study show that SPJ reduced the production of ROS by increase the expression of antioxidants and restore the balance between prooxidants and antioxidants via activation of the Nrf-2 pathway. Furthermore, SPJ might reduce ROS production and apoptosis in hydrogen peroxide-induced H9c2 cells. The effect of MI apoptotic cells induces generation of ROS in abundance. Taken together, SPJ treatment significantly improved MI-induced injury and this may be attributing to inhibiting ROS related apoptosis via activation of the Nrf-2 pathway.

• Periodical: Advanced Materials Research (Volumes 881-883)
• Pages: 339-346
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.881-883.339
• Online since: January 2014
• Authors: Na Wei, Ding Yuan, Hai Bo He*, Yuan Qing Xu, Chang Cheng Zhang, Ting Wang, Chao Qi Liu, Guang Yao Liu
• Keywords: Apoptosis, Myocardial Infarction (MI), Nrf-2, ROS, Saponins from Panax japonicus (SPJ)

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