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Synthesis Podophyllotoxin Derivatives via “Click Chemistry”

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Abstract:

1,2,3-Triazole linked carbohydrate and podophyllotoxin were synthesized in high yield and selectivity. The CuI-catalyzed Huisgen’s [2+3] cycloaddition of azides and alkynes was proved to be powerful tool for constructing podophyllotoxin derivatives.

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Periodical:

Advanced Materials Research (Volumes 881-883)

Pages:

400-404

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.881-883.400

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Online since:

January 2014

Authors:

Ru Chun Yang, Hai Xin Ding, Yan Li Wu, Qiang Xiao*

Keywords:

Antitumor, Carbohydrate, Click Chemistry, Conjugation, Podophyllotoxin

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© 2014 Trans Tech Publications Ltd. All Rights Reserved

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