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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 881-883Synthesis of Bicyclic Furo[2,3-d]pyrimidine...

Synthesis of Bicyclic Furo[2,3-d]pyrimidine Deoxynucleosides Conjugated with N-Diisopropylphosphoryl Amino Acids

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Abstract:

A series of bicyclic furo[2,3-d]pyrimidine nucleosides conjugated with N-diisopropylphosphoryl amino acids were synthesized from 2′-deoxy-5-iodouridine. The key step is its cross coupling with the 5-phthalimido-1-pentyne under Sonogashira reaction condition. 5-Endo-dig electrophilic cyclization catalyzed by AgNO₃ is used to afford the furo[2,3-d]pyrimidines.

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Periodical:

Advanced Materials Research (Volumes 881-883)

Pages:

405-409

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.881-883.405

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Online since:

January 2014

Authors:

Ru Chun Yang, Hui Zhu, Xuan Ye Jin, Qiang Xiao*, Yong Ju

Keywords:

Antiviral, Furo[2,3-d]pyrimidine, N-Diisopropylphosphoryl Amino Acid, Nucleoside, Sonogashira Reaction

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© 2014 Trans Tech Publications Ltd. All Rights Reserved

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