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Facile Synthesis, Characterization and Anti-Inflammatory Effect of 3-Aminoindolizine Derivatives
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Facile Synthesis, Characterization and Anti-Inflammatory Effect of 3-Aminoindolizine Derivatives

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Abstract:

Four 3-aminoindolizines were synthesized from the substituted 2-bromopyridines and propargyl amines with the aim of obtaining potential anti-inflammatory compounds, which were characterized by NMR, IR, ESI-MS and elemental analysis. Their biological activities were evaluated by the bacterial lipopolysaccharide (LPS) stimulation of mouse cells in the RAW264.7 inflammation model. The target compounds 4a-4d revealed moderate anti-inflammatory effects with the inhibitions of 45%~61% at 50 μM. The bioactive 3-aminoindolizines might be used for further optimization as potential anti-inflammatory drugs.

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Periodical:

Advanced Materials Research (Volumes 881-883)

Pages:

446-449

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.881-883.446

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Online since:

January 2014

Authors:

Yong Wei, Cheng Qiao Cao, Xiao Feng Lu, Zheng Yang, Kun Zou, Nian Yu Huang*

Keywords:

3-aminoindolizine, Anti-Inflammatory Agents, IL-6 Inhibitors, Synthesis

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© 2014 Trans Tech Publications Ltd. All Rights Reserved

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