Production of Personalized Thyroid Cartilage Scaffold and Histological Analysis

Wei Xia; Gao Xiang Cao; Long Cheng Zhang; Jie Liao; Jian Min Zeng

doi:10.4028/www.scientific.net/AMR.881-883.473

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 881-883Production of Personalized Thyroid Cartilage...

Production of Personalized Thyroid Cartilage Scaffold and Histological Analysis

Abstract:

To meet the bone defect on the personalized needs of implantation, this study presents the manufacture of personalized thyroid cartilage hydroxyapatite (HA) scaffold by the rapid prototyping(RP) technique combined with CT image reconstruction and employs the foaming of suspensions prior to the in situ polymerization of organic monomers contained in the compositions. The organic additives are eliminated at temperatures above 300°C, and sintering is carried out for consolidation of the ceramic matrix. Spherical interconnected cells with sizes ranging from 100μm to 250μm characterize the porous structure, depending on the specimen density. The biological properties of porous personalized scaffolds loaded with bone morphogenetic protein 2 (rhBMP-2) were evaluated, by which a simulated surgical method of thyroid cartilage defects in rabbits and repairing with artificial scaffolds, and compared with rhBMP-2 loaded dense personalized or porous non-personalized scaffolds. The results of the histological analysis and the electronic laryngoscope inspection of airway indicate that rhBMP-2/HA/ porous personalized scaffolds is a promising composite having osteogenic efficient enough for repairing thyroid cartilage defects.

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Periodical:

Advanced Materials Research (Volumes 881-883)

Pages:

473-478

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.881-883.473

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Online since:

January 2014

Authors:

Wei Xia, Gao Xiang Cao*, Long Cheng Zhang, Jie Liao, Jian Min Zeng

Keywords:

Bone Implants, Gel-Cast Foams, Hydroxyapatite (HA), Personalized Scaffolds, rhBMP-2

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