Derivatives of Hydantoin: Synthesis and Antiproliferative Activity on HepG2 Cancer Cell Line

Lu Jiang; Bin Zeng

doi:10.4028/www.scientific.net/AMR.893.512

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 893Derivatives of Hydantoin: Synthesis and...

Derivatives of Hydantoin: Synthesis and Antiproliferative Activity on HepG2 Cancer Cell Line

Abstract:

Based on the study of rhodanine derivative WL-276,some novel compounds were synthesized,and their anti-tumor effects were screened by MTT method. Hydantoin is rhodanine of electronic derivative. Compounds of 3a-3d were obtained by Aldol reaction, whose structures were confirmed by 1H-NMR. Furthermore, preliminary pharmacological results suggested that compounds 2a had strong inhibitory effects on the proliferation of HepG2 tumor cells.

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Advanced Materials and Engineering Materials III

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Periodical:

Advanced Materials Research (Volume 893)

Pages:

512-515

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.893.512

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Online since:

February 2014

Authors:

Lu Jiang, Bin Zeng*

Keywords:

Anti-Tumor Activity, Hydantoin Derivatives, Synthesis

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