Inhibiting Effects of Taurine on Doxorubicin-Induced Oxidative Stress in Rats

Yan Chun Wang; Kuang Ren; Qian Lu; Hong Yan Fan; Nan Shen

doi:10.4028/www.scientific.net/AMR.912-914.214

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 912-914Inhibiting Effects of Taurine on...

Inhibiting Effects of Taurine on Doxorubicin-Induced Oxidative Stress in Rats

Abstract:

The study was designed to observethe protective effect of taurine(Tau) against doxorubicin-induced cardiotoxicity in rats.Doxorubicin were administered at the dosage of 2.5 mg·kg^-1 oncea week, ip for a period of 4 consecutive weeks. Taurine were administered atthe dosages of400,200and 100 mg·kg^-1·d^-1, poby gavage for 30 consecutive days. Taurine at the doses of 400 and 200 mg·kg^-1significantly reduced CK-MB, GOT and LDH and increased SOD levelsin the doxorubicin-treated animals. Thus, taurine ameliorated doxorubicin-induced cardiotoxicity by reducingoxidative stress, abnormal cellular morphology in rat. The study show the protective effect oftaurine against doxorubicin-induced cardiotoxicity.

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Periodical:

Advanced Materials Research (Volumes 912-914)

Pages:

214-216

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.912-914.214

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Online since:

April 2014

Authors:

Yan Chun Wang, Kuang Ren*, Qian Lu, Hong Yan Fan, Nan Shen

Keywords:

Doxorubicin, Lipid Peroxidation, Taurine

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* - Corresponding Author

References

[1] Fan, G. C., Zhou, X., Wang, X., Song, G., Qian, J., Nicolaou, P., et al. Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity. Circulation Research, 103, 1270–1279. (2008).

DOI: 10.1161/circresaha.108.182832

Google Scholar

[2] P. P. Trivedi, S. Kushwaha, D. N. Tripathi, G. B. Jena. Cardioprotective Effects of Hesperetin against Doxorubicin-Induced Oxidative Stress and DNA Damage in Rat. Cardiovasc Toxicol 11: 215–225. (2011).

DOI: 10.1007/s12012-011-9114-2

Google Scholar

[3] Alkreathy, H., Damanhouri, Z. A., Ahmed, N., Slevin, M., Ali, S.S., & Osman, A. M. Aged garlic extract protects against doxorubicin-induced cardiotoxicity in rats. Food and Chemical Toxicology, 48, 951–956. (2010).

DOI: 10.1016/j.fct.2010.01.005

Google Scholar

[4] FAN Hong-yan，REN Kuang, GU Rao-sheng, et al. Inhibiting Effect of Taurine on Myocarditis and Myocardial Fibrosis Followed by Myocarditis. Chinese PharmaceuticalJournal, 2010，45 (13），36-40.

Google Scholar

[5] WAN F S, ZENG J Z, ZHAO X M. Effects of Taurine on dysfunction of myocardial nuclear calcium transport in rat myocardial injury induced with isoproterenol . Chinese Journal of Clinical Pharmacology and Therapeutics, 2000, 5(1), 25-27.

Google Scholar