Characterization of Different Nanostructured Bone Substitute Biomaterials

Abstract:

The present research paper centers on physicochemical characterization of six nanostructured alloplastic bone substitutes developed at Santa Catarina State University (UDESC Brazil). In addition to identifying the main phases, the focus was to measure the morphological and microstructural features, which are believed to be crucial for controlling and guiding biological and molecular events. The studied samples exhibited rounded granules measuring 200μm 10(PO₄)₆(OH)₂] was found as main phase for HAp, BCP and HAp/Al₂O₃ biomaterials. For HAp/TiO2n, HAp/SiO₂n and β-TCP, the major phase was beta tricalcium phosphate [Ca₃(PO₄)₂-β]. The results demonstrate that the presence of a second phase of nanometer order, at a hydroxyapatite bioceramic matrix, may modify the surface diffusion of the grains and the phase transformation kinetics of hydroxyapatite and beta tricalcium phosphate at temperatures up to 1100°C.

• Periodical: Advanced Materials Research (Volume 936)
• Pages: 695-700
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.936.695
• Online since: June 2014
• Authors: Nelson Levandowski, Nelson H.A. Camargo, Daiara F. Silva, Gisele M.L. Dalmônico, Priscila F. Franczak
• Keywords: Biomaterial, Bone Substitute, Calcium Phosphate, Hydroxyapatite (HA), Nanostructure

References

[1] L. Zhang, T.J. Webster. Nanotechnology and nanomaterials: Promises for improved tissue regeneration. Nano Today, 4 (2009) 66-80.

DOI: 10.1016/j.nantod.2008.10.014

[2] R.Z. Legeros, G. Daculsi, J.P. Legeros. Bioactive Bioceramics. In W.S. Pietrzak. Musculo-skeletal tissue regeneration: biological materials and methods, Humana Press, Totowa, (2008).

DOI: 10.1007/978-1-59745-239-7_8

[3] H. Yuan, K. Kurashina, J. D. de Bruijn, Y. Li, K. de Groot, X. Zhang. A preliminary study on osteoinduction of two kinds of calcium phosphate ceramics. Biomaterials, (20) 1999 1799-1806.

DOI: 10.1016/s0142-9612(99)00075-7

[4] D. Le Nihouannen, G. Daculsi, A. Saffarzadeh, O. Gauthier, S. Delplace, P. Pileta, P. Layrolle. Ectopic bone formation by microporous calcium phosphate ceramic particles in sheep muscles. Bone 36 (2005) 1086-1093.

DOI: 10.1016/j.bone.2005.02.017

[5] K. A Hing, B. Annaz, S. Saeed, P.A. Revell, T. Buckland. Microporosity enhances bioactivity of synthetic bone graft substitutes. Journal of Materials Science: Materials in Medicine, 16 (2005) 467– 475.

DOI: 10.1007/s10856-005-6988-1

[6] L. Richert, F. Variola, F. Rosei, J. D. Wuestd, A. Nanci. Adsorption of proteins on nanoporous Ti surfaces. Surface Science 604 (2010) 1445–1451.

DOI: 10.1016/j.susc.2010.05.007

[7] Z. Evis, M. Sato, T. J. Webster. Increased osteoblast adhesion on nanograined hydroxyapatite and partially stabilized zirconia composites. J Biomed Mater Res A, 78 (2006) 500-507.

DOI: 10.1002/jbm.a.30750

[8] J.W. Park, E.S. Kim, J.H. Jang, J.Y. Suh, K.B. Park, T. Hanawa. Healing of rabbit calvarial bone defects using biphasic calcium phosphate ceramics made of submicron-sized grains with a hierarchical pore structure. Clin. Oral. Implants Res. 21 (2010).

DOI: 10.1111/j.1600-0501.2009.01846.x

[9] N. Kivrak, A. C. Tas. Synthesis of Calcium Hydroxyapatite–Tricalcium Phosphate (HA–TCP) Composite Bioceramic Powders and Their Sintering Behavior. J. Am. Ceram. Soc., 81 (1998) 2245–52.

DOI: 10.1111/j.1151-2916.1998.tb02618.x

[10] S. Raynaud, E. Champion, D. Bernache-Assollant. Calcium phosphate apatites with variable Ca/P atomic ratio II. Calcination and sintering. Biomaterials 23 (2002) 1073-1080.

DOI: 10.1016/s0142-9612(01)00219-8

[11] J Peña, M. Vallet-Regi. Hydroxyapatite, tricalcium phosphate and biphasic materials prepared by a liquid mix technique. Journal of the European Ceramic Society, 23 (2003) 1687-1696.

DOI: 10.1016/s0955-2219(02)00369-2

[12] P. Layrolle, G. Daculsi. Physicochemistry of Apatite and Its Related Calcium Phosphates. In: B. León, J.A. Jansen. Thin calcium phosphate coatings for medical implants. Springer, New York, (2009).

DOI: 10.1007/978-0-387-77718-4_2