The Effects of a Mixture of Ferulic Acid and Gastrodin on Spontaneous Activity in Mice

Lin Liu; Dong Xue Wang; Ju Huo; Ying Zhao

doi:10.4028/www.scientific.net/AMR.955-959.736

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 955-959The Effects of a Mixture of Ferulic Acid and...

The Effects of a Mixture of Ferulic Acid and Gastrodin on Spontaneous Activity in Mice

Abstract:

Objective: To study the effects of a mixture of ferulic acid and gastrodin on spontaneous activity in mice, we explored the pharmacological effects on the central nervous system. Methods: 50 healthy adult mice were randomly divided into five groups, each 10 mixture times the dose groups, respectively. The negative control group (ig same volume of saline) (ig ferulic acid 0.76mg • kg^-1, gastrodin 1.06mg • kg^-1), a 2-fold dose group (ig ferulic acid 1.52mg • kg^-1, gastrodin 2.12mg • kg^-1), 4-fold dose group (ig ferulic acid 3.04mg • kg^-1, gastrodin 4.24mg • kg^-1), 8-fold dose group (ig ferulic acid 6.08mg • kg^-1, gastrodin 8.48mg • kg^-1). We measured the spontaneous activity in mice before and after the administration of 10min, 20min, 30min, 40min, 50min, 60min, 80min, 100min, 120min, 180min, 240min, 360min. Results: Compared with the negative control group, there was a significant excitatory effect in 1-fold dose of spontaneous activity in mice in 60min, 80min, 100min (P<0.05, P<0.01); while 4-fold and 8-fold dose in 80min (P<0.05, P<0.01). Conclusions: There was an exciting effect of a mixture of ferulic acid and gastrodin in a certain dose range, but not in a dose-dependent manner.

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Periodical:

Advanced Materials Research (Volumes 955-959)

Pages:

736-739

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.955-959.736

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Online since:

June 2014

Authors:

Lin Liu, Dong Xue Wang, Ju Huo, Ying Zhao

Keywords:

Ferulic Acid, Gastrodin, Spontaneous Activity

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