Preparation and In Vitro Release Behaviors of Paclitaxel-Loaded Pluronic F87/Poly(Lactic Acid) Nanoparticle

Zi Ling Li; You Sheng Huang; Xiang Yuan Xiong; Yan Chun Gong; Yu Ping Li

doi:10.4028/www.scientific.net/AMR.989-994.102

Paper Titles

Efficient Synthesis 2,3-Dihydroquinazolin-4(1H)-Ones Using Coconut Shell Char Sulfonic Acid as a Reusable Catalyst in Ethanol
p.83

Study on the Urea Demand Model of SCR Control Technology
p.87

Effect of Sodium Methylacrysulfonate upon the Molecular Weight and Performance of Polycarboxylate Superplasticizer
p.91

Influence of the pH Value on the Water-Reducing Performance of Polycarboxylate-Based Superplasticizers at Room Temperature
p.97

Preparation and In Vitro Release Behaviors of Paclitaxel-Loaded Pluronic F87/Poly(Lactic Acid) Nanoparticle
p.102

Application of High-Efficiency Reverse Osmosis Technology in Reclaimed Water Treatment in Power Plants
p.108

Measurement of Ultra Low Sulfur in IN718 by Using Infrared Absorption Method
p.115

The Synthesis and Characterization of Polyphenylene Vinylene (PPV) Derivatives with Alkoxy Branched Chains
p.121

Comparison and Characterization of Two Preparation Methods of Graphene Oxide
p.125

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 989-994Preparation and In Vitro Release Behaviors of...

Preparation and In Vitro Release Behaviors of Paclitaxel-Loaded Pluronic F87/Poly(Lactic Acid) Nanoparticle

Abstract:

Pluronic F87/Poly (lactic acid) block copolymer (PLA-F87-PLA) was synthesized by bulk polymerization. Paclitaxel-loaded PLA-F87-PLA nanoparcticles were prepared by a dialysis method. The loading efficiency was determined by UV. The results showed that the loading efficiency of paclitaxel for PLA-F87-PLA nanoparticles was 69%. In vitro release behavior of paclitaxel-loaded PLA-F87-PLA nanoparticles was studied by HPLC. In vitro release behavior showed an initial rapid release followed by a slow release. The biocompatibility of nanoparticles was measured by MTT. The viability of paclitaxel-loaded PLA-F87-PLA nanoparticles was less than that of free paclitaxel. The results indicated that PLA-F87-PLA copolymer has good biocompatibility.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Advanced Materials Research (Volumes 989-994)

Pages:

102-107

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.989-994.102

Citation:

Cite this paper

Online since:

July 2014

Authors:

Zi Ling Li, You Sheng Huang, Xiang Yuan Xiong*, Yan Chun Gong, Yu Ping Li

Keywords:

Block Copolymer, In Vitro Release, Paclitaxel, PLA, Pluronic F87

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

* - Corresponding Author

References

[1] Xiong XY, Li YP, Li ZL, et al. Vesicles from Pluronic/poly(lactic acid) block copolymers as new carriers for oral insulin delivery[J]. J Control Release. 2007; 120(1-2): 11-17.

DOI: 10.1016/j.jconrel.2007.04.004

Google Scholar

[2] Fabienne Danhier, Nathalie Lecouturier, Benoît Vroman. et al Paclitaxel-loaded PEGylated PLGA-based nanoparticles: In vitro and in vivo evaluation[J]. Journal of Controlled Release. 2009, 133: 11–17.

DOI: 10.1016/j.jconrel.2008.09.086

Google Scholar

[3] Soo Young Lee, Hoon Hyuna, , Ju Yong Youn et al. Preparation of nano-emulsified paclitaxel using MPEG–PLGA diblock copolymers. Colloids and Surfaces A, Physicochem. Eng. Aspects 2008, 313–314: 126–130.

DOI: 10.1016/j.colsurfa.2007.04.157

Google Scholar

[4] XIN ShCh, WU XR, ZHOU LZh. Preparation of magnetic solid liposome nanoparticles of paclitaxel[J]. Acta Pharmaceutica Sinica 2006, 41 (10) : 933 - 938.

Google Scholar

[5] Jong-Ho Kim, Yoo-Shin Kim, Sungwon Kim et al. Hydrophobically modified glycol chitosan nanoparticles as carriers for paclitaxel[J]. Journal of Controlled Release. 2006, 111: 228–234.

DOI: 10.1016/j.jconrel.2005.12.013

Google Scholar

[6] WANG YZh, FANG XL Li YJ, et al. Preparation, character ization of paclitaxel2loaded Pluron ic P105 polymer ic m icelles and in vitro reversal of multidrug resistant tumor[J] Acta Pharmaceutica Sinica 2008, 43 (6) : 640 - 646.

Google Scholar

[7] X. Y. Xiong, K. C. Tam, L. H. Gan. Polymeric Nanostructures for Drug Delivery Applications Based on Pluronic Copolymer Systems[J]. Journal of Nanoscience and Nanotechnology. 2006,. 6: 2638–2650.

DOI: 10.1166/jnn.2006.449

Google Scholar

[8] J.R. DesNoyer, A.J. McHugh. The effect of Pluronic on the protein release kinetics of an injectable drug delivery system[J]. Journal of Controlled Release. 2003, 86: 15–24.

DOI: 10.1016/s0168-3659(02)00293-6

Google Scholar

[9] Alexandre Marin, Hao Sun, Ghaleb A. Husseini et al. Drug delivery in pluronic micelles: effect of high-frequency ultrasound on drug release from micelles and intracellular uptake[J]. Journal of Controlled Release. 2002, 84: 39–47.

DOI: 10.1016/s0168-3659(02)00262-6

Google Scholar