Biodistribution and Toxicity Study of Titanium Dioxide Nanoparticles of Different Sizes after Intravenous Injection in Mice

Abstract:

Titanium dioxide nanoparticles (TiO₂-NPs) are widely used in many fields. The bio-distribution and toxicology of different sizes (25 nm and 50 nm) of TiO₂-NPs in vivo is evaluated in this paper. The results of quantitative distribution in vivo show that it is difficult for TiO₂-NPs to excretion clearly from tissues and organs. At the endpoint of experiment of different groups, there are still many TiO₂-NPs located in the main organs such as spleen, liver and lung after 120 days. Blood biochemical parameters keep unchanged compared with control group. However, pathological results show that lesions in spleen, liver and lung where TiO₂-NPs particles are mainly accumulated and retained are getting serious with the time prolonging. The results indicate that TiO₂-NPs are low toxic to mice but may have some potential effects on liver and kidney functions after exposure long time. The fundamental importance information gained from such a study will give the guidance on the application of TiO₂-NPs.

• Periodical: Advanced Materials Research (Volumes 998-999)
• Pages: 196-199
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.998-999.196
• Online since: July 2014
• Authors: Jie Fang, Lu Lu Yuan, Chen Jie Yao, Yan Li Wang*, Ming Hong Wu
• Keywords: In Vivo, Nanosafety, Titanium Dioxide Nanoparticles, Toxicity

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