Development of Nanosystems to Release Atenolol

Richard. W. Novickis; Marcos V. Surmani Martins; Leila F. de Miranda; Roberto R. Ribeiro; Laureano Silva; Antônio Hortêncio Munhoz Jr.

doi:10.4028/www.scientific.net/AST.86.102

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Development of Nanosystems to Release Atenolol
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HomeAdvances in Science and TechnologyAdvances in Science and Technology Vol. 86Development of Nanosystems to Release Atenolol

Development of Nanosystems to Release Atenolol

Abstract:

Abstract: The structure of aluminum monohydroxide resulting from synthesis by ammonium hydroxide with aluminum chloride (or aluminum nitrate, for example) by a sol-gel process, gives a purified and chemically inert material with many applications possibilities because of its great specific surface area. A pseudoboehmite is the choice in this project for adsorption/desorption of atenolol. The molecular interaction with the pseudoboehmite substrate was studied by FTIR (Infrared Spectroscopy), DSC (Scanning electron /TG Thermogravimetry), UV-vis (Ultraviolet-visible spectroscopy) and SEM (Scanning Electron Microscopy). The SEM characterization has been used to quantify the local structural surface for the correlations with the synthesis process; and the Spectroscopies and Thermogravimetric techniques were used for measurements of the adsorption/desorption concentrations of the drug in physiological solution. This procedure gives information to the chemistry and surface of these fine ceramics material that would be applied like excipient in medications to control the drug delivery and plasmatic concentrations in optimal conditions.

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Periodical:

Advances in Science and Technology (Volume 86)

Pages:

102-107

DOI:

https://doi.org/10.4028/www.scientific.net/AST.86.102

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Online since:

September 2012

Authors:

Richard. W. Novickis, Marcos V. Surmani Martins, Leila F. de Miranda, Roberto R. Ribeiro, Laureano Silva, Antônio Hortêncio Munhoz Jr.

Keywords:

Atenolol, Drug Delivery Systems, Pseudoboehmite

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References

[1] MUNHOZ JR, A. H., MIRANDA, L. F., UEHARA, G. N. Study of pseudoboehmite by sol-gel synthesis. AST - Advances in Science and Technology. , v.45, pp.260-265, 2006.

Google Scholar

[2] THEO KLOPROGGE, J.; DUONG, L.V.; WOOD, B.J.; FROST, R.L. XPS study of the major minerals in bauxite Gibbsite, bayerite and (pseudo-)boehmite, Journal of colloid and interface Science, v. 296, pp.572-576, 2006.

DOI: 10.1016/j.jcis.2005.09.054

Google Scholar

[3] MOROZ, E.M.; SHEFER, K.I.; ZYUZIN, DMITRY A.; IVANOVA, ALEKSANDRA S.; KULKO, EUGENIA V.; GOIDIN, VASILY V. and OLCHANOV, VIKTOR V. Local structureof pseudoboehmites, React.Kinet.Catal.Lett, Vol. 87, No. 2, 367-375, (2006).

DOI: 10.1007/s11144-006-0045-z

Google Scholar

[4] PEREIRA, R.N. et al Thermoanalytical study of atenolol and commercial tablets, Lat.Am.J.Pharm.26 (3), pp.382-6, 2007.

Google Scholar

[5] MUNHOZ JR, A. H. ; Peres, Renato Meneghetti ; Faldini, Sonia B. ; Andrade e Silva, Leonardo Gondim ; Aguiar, Amanda Abati ; de Miranda, Leila Figueiredo . Synthesis of g-Alumina Powder Obtained from Irradiated Pseudoboehmites. Materials Science Forum, v. 660-661, pp.928-935, 2010.

DOI: 10.4028/www.scientific.net/msf.660-661.928

Google Scholar