Application of α-TCP/HAp Functionally Graded Porous Beads for Bone Regenerative Scaffold

Abstract:

α-TCP/HAp functionally graded porous beads were prepared for use as a scaffold for bone regeneration. In this research, porous beads which have compositionally graded layer, from TCP of inner area to HAp of surface area, were fabricated. It is known that the dissolution rate of TCP is fast in compare with that of HAp in living body, thus the inner area would dissolve prior to the surface area. These beads to allow the penetration of cells and blood vessel into the inner area of beads following new bone regeneration. At present, conditions to fabricate the functionally graded porous beads have been established already, and experiments using cells [MC3T3-E1] are in progress.

• Periodical: Advances in Science and Technology (Volume 86)
• Pages: 63-69
• DOI: https://doi.org/10.4028/www.scientific.net/AST.86.63
• Online since: September 2012
• Authors: A. Tamura, Teruo Asaoka, K. Furukawa, T. Ushida, T. Tateishi
• Keywords: DAPI, HAp, RT-PCR, SEM, TCP, X-Ray Diffraction (XRD)

References

[1] Qing Fu Mohamed N. Rahaman, B. Sonny Bal, Roger F. Brown, In vitro cellular response to hydroxyapatite scaffolds with oriented pore architectures, Materials Science and Engineering C 29 (2009) 2147-2153

DOI: 10.1016/j.msec.2009.04.016

[2] Roger F. Browm, Delbert E, Thomas E. Steve Jung Mohamed N. Rahaman. Qiang Fu, Acta Growth and differentiation of osteoblastic cells on 13-93 bioactive glass fibers and scaffolds, Biomaterialia 4 (2008) 387-396

DOI: 10.1016/j.actbio.2007.07.006

[3] Yan Zhaoa, Bing Zoua, Zhenyu Shia, Qiong Wua, Guo-Qiang Chen, The effect of 3-hydroxybutyrate on the in vitro differentiation of murine osteoblast MC3T3-E1 and in vivo bone formation in ovariectomized rats, Biomaterials 28 (2007) 3063-3073

DOI: 10.1016/j.biomaterials.2007.03.003

[4] Y. Tsutsumi, D. Nishimura, H. Doi, N. Nomura, T. Hanawa, Difference in surface reactions between titanium and zirconium in Hanks' solution to elucidate mechanism of calcium phosphate formaition on titanium using XPS and, cathodic polarization Materials Sience and Engineering C 29 (2009) 1702-1708

DOI: 10.1016/j.msec.2009.01.016

[5] Elena I. Suvorova, Natalya A. Arkharova, Philippe A. Buffat, Transmission electron microscopy of Ca oxide nano- and microcrystals in a-tricalcium phosphate prepared by sintering of b- tricalcium phosphate Micron xxx(2009)xxx-xxx

DOI: 10.1016/j.micron.2009.03.002