Nanotechnology Enabled In Situ Orthopaedic Sensors for Personalized Medicine

Abstract:

Although improvements have been made in implant design to increase bone formation and promote successful osseointegration using nanotechnology, the clinical diagnosis of early bone growth surrounding implants remains problematic. The development of a device allowing doctors to monitor the healing cascade and to diagnose potential infection or inflammation is necessary. Biological detection can be examined by the electrochemical analysis of electron transfer (or redox) reactions of extracellular matrix proteins involved in bone deposition and resorption. The use of nanomaterials as signal amplifiers in electrochemical sensors has greatly improved the sensitivity of detection. Nanotechnology-enabled electrochemical sensors that can be placed on the implant surface itself show promise as self-diagnosing devices in situ, possibly to detect new bone growth surrounding the implant and other cellular events to ensure implant success.

• Periodical: Advances in Science and Technology (Volume 86)
• Pages: 40-50
• DOI: https://doi.org/10.4028/www.scientific.net/AST.86.40
• Online since: September 2012
• Authors: Sirinrath Sirivisoot, Thomas J. Webster
• Keywords: Carbon Nanotube (CN), Extracellular Matrix, Non-Collagenous Protein in Bone, Orthopedic Implant, Osteoblast, Redox, Titanium

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