Design of Biodegradable Injectable Polymers Exhibiting Temperature-Responsive Sol-Gel Transition

Abstract:

Starburst triblock copolymers consisting of 8-arm poly(ethylene glycol) (8-arm PEG), poly(L-lactide) (PLLA) or its enantiomer poly(D-lactide) (PDLA) and terminal PEG, 8-arm PEG-b-PLLA-b-PEG (Stri-L) and 8-arm PEG-b- PDLA-b-PEG (Stri-D), were synthesized. An aqueous solution of a 1:1 mixture (Stri-Mix) of Stri-L and Stri-D assumed a sol state at room temperature, but instantaneously formed a physically cross-linked hydrogel in response to increasing temperature. The resulting hydrogel exhibited a high storage modulus at 37 °C. The rapid temperature-triggered hydrogel formation, high mechanical strength, and degradation behavior render this polymer system suitable for use in injectable drug delivery system or a biodegradable scaffold for tissue engineering.

• Periodical: Advances in Science and Technology (Volume 86)
• Pages: 9-16
• DOI: https://doi.org/10.4028/www.scientific.net/AST.86.9
• Online since: September 2012
• Authors: Yuichi Ohya, Hiroyuki Suzuki, Koji Nagahama, Akihiro Takahashi, Tatsuro Ouchi, Akinori Kuzuya
• Keywords: Biodegradable Polymer, Injectable Polymers, Poly(ethylene glycol) (PEG), Polylactide, Stereocomplex, Temperature-Responsive Sol-Gel Transition

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