Validation of Velocity in Microchannels with a Retention System due to Unevenness Manufactured by 3D Printing (SLA)

Abstract:

Microfluidics is an efficient technology for controlling fluid movement in microchannels at extremely low speeds. The main advantage lies in the significant reduction of samples and reagents, thereby reducing costs and analysis times. Three devices with retention systems are introduced that are manufactured through 3D printing (SLA) incorporating microchannels with variations in levels and dimensions. Fluid velocity is studied, considering factors such as channel width, length, rounding, height, and shape. The analysis of velocity along the channel reveals liquid retention at the devices' maximum point, ensuring more precise results in microdevices.

• Periodical: Defect and Diffusion Forum (Volume 439)
• Pages: 243-260
• DOI: https://doi.org/10.4028/p-5TTke0
• Online since: February 2025
• Authors: Samia Antonela Ramos-Ocaña*, Víctor H. Cabrera-Moreta
• Keywords: Microfluidics, Retention, SLA, Slope, Speed

References

[1] H. Bruus, Theoretical microfluidics, Lecture notes, Third edition, vol. 6 (2004).

[2] B. Heidt et al., The Liberalization of Microfluidics: Form 2 Benchtop 3D Printing as an Affordable Alternative to Established Manufacturing Methods, Phys. Status Solidi A, 217.

DOI: 10.1002/pssa.201900935

[3] S. B. Berry, J. J. Lee, J. Berthier, E. Berthier, and A. B. Theberge, Droplet incubation and splitting in open microfluidic channels, Analytical Methods, 11 (2019) 4528–4536.

DOI: 10.1039/c9ay00758j

[4] M. J. Beauchamp, A. V. Nielsen, H. Gong, G. P. Nordin, and A. T. Woolley, 3D Printed Microfluidic Devices for Microchip Electrophoresis of Preterm Birth Biomarkers, Anal Chem, 91 (2019) 7418–7425.

DOI: 10.1021/acs.analchem.9b01395

[5] O. A. Al-wdan, O. A. Sharallah, N. A. Abdelwahab, A. O. Mohammed, E. Elmowafy, and M. E. Soliman, Insights into microfabrication and implementation of microfluidics in pharmaceutical drug delivery and analysis, OpenNano, 12 (2023) 100156.

DOI: 10.1016/j.onano.2023.100156

[6] M. Bucco, La impresión 3D y su aplicación en los servicios médicos (prótesis, fármacos, órganos), 2016.

[7] A. Hawke, G. Concilia, P. Thurgood, A. Ahnood, S. Baratchi, and K. Khoshmanesh, A 3D printed flow sensor for microfluidic applications, Sens Actuators A Phys, 362 (2023).

DOI: 10.1016/j.sna.2023.114686

[8] E. A. Galan, H. Zhao, X. Wang, Q. Dai, W. T. S. Huck, and S. Ma, Intelligent Microfluidics: The Convergence of Machine Learning and Microfluidics in Materials Science and Biomedicine," Matter, Cell Press, 3 (2020) 1893–1922.

DOI: 10.1016/j.matt.2020.08.034

[9] B. Evans, Practical 3D printers: The Science and Art of 3D Printing, Apress, 2012.

[10] A. Ortiz, Las impresoras 3D como herramientas científicas, Dialnet, 21(2019).

[11] J. Prusa, ¿Qué es la impresión 3D?, The Future of Manufacturing. 2023. [Online]. Available: https://afs.prusa3d.com/es/info/que-es-la-impresion-3d

[12] R. Valverde, IMPRESORAS 3D: Marco teórico, modelos de desarrollo y campos de aplicación Nuevas prácticas culturales y artísticas Tesis realizada por Roxana Valverde Ponce.

[13] Craftcloud, Tipos de impresoras 3D: las 7 tecnologías de impresión 3D., ALL3DP. 2023. [Online]. Available: https://all3dp.com/es/1/tipos-de-impresoras-3d-tecnologia-de-impresion-3d/

DOI: 10.2307/jj.5076228.4

[14] Microfluídica: Descripción General, Malvern Panalytical. 2023. [Online]. Available: https://www.malvernpanalytical.com/es/products/technology/microfluidics

[15] E. A. Galan, H. Zhao, X. Wang, Q. Dai, W. T. S. Huck, and S. Ma, Intelligent Microfluidics: The Convergence of Machine Learning and Microfluidics in Materials Science and Biomedicine, Matter, 3 (2020) 1893–1922.

DOI: 10.1016/j.matt.2020.08.034

[16] C. Cárdenas, Microfluídica: el arte de fluir en espacios diminutos, Stamm. 2023. [Online]. Available: https://www.stamm.bio/es/microfluidica-el-arte-de-fluir-en-espacios-diminutos/

DOI: 10.4995/thesis/10251/61767

[17] Guía de microfluídica, milifluídica y fabricación de laboratorio en un chip, formlabs. 2023. [Online]. Available: https://formlabs.com/latam/blog/microfluidica-milifluidica-fabricacion-laboratorio-chip/

[18] K. Oh, K. Lee, B. Ahn, and E. Furlani, Design of pressure-driven microfluidic networks using electric circuit analogy, Lab Chip, 12 (2012) 515–545.

DOI: 10.1039/c2lc20799k

[19] Un dispositivo microfluídico puede revolucionar los diagnósticos, SaluDigital. 2023. [Online]. Available: https://www.consalud.es/saludigital/tecnologia-sanitaria/un-dispositivo-microfluidico-puede-revolucionar-los-diagnosticos_54081_102.html

[20] P. Juárez Jiménez and D. T. De, DISPOSITIVO MICROFLÍDICO MODULAR. LAB-ON-A-CHIP, UPM (2018).

[21] J. David, J. Díaz, H. Alonso, and C. Bañol, Numero de Reynolds, 2015.

[22] J. Bernal, Manufactura Aditiva: Innovación y Eficiencia en la Fabricación 3D, Tecnología del Plástico. 2023. [Online]. Available: https://www.plastico.com/es/noticias/manufactura-aditiva-como-proceso-productivo-una-realidad

[23] F. Rupp et al., A review on the wettability of dental implant surfaces I: Theoretical and experimental aspects, Acta Biomaterialia, 10 (2014) 2894–2906.

DOI: 10.1016/j.actbio.2014.02.040