Propolis Bioactive Compounds of Stingless Bees (Tetragonula laeviceps) from Mount Merapi Slope, Sleman, Yogyakarta

Article Preview

Abstract:

The emergence of many new diseases due to viruses and bacteria demands for an increase in the discovery of natural alternative medicines. One example of sources of natural medicine is the honey and the propolis of Tetragonula laeviceps bee. The efficacy, physical and chemical properties of honey are known to be influenced by the type of pollen and the environment whilst the composition of propolis is influenced by the geological factors. Therefore, the purpose of this research was to study the composition of propolis’ bioactive compounds of T.laeviceps bee from Mount Merapi Slope, Sleman, Yogyakarta. The bioactive compound composition of the propolis sample were analysed by Gas Chromatograph-Mass Spectrometry (GC-MS). The analysis showed that the propolis has various type of compounds containing up to 20 bioactive compounds which can be classified in three different groups namely alkaloids (70%), phenolics (20%), and terpenoids (5%). Most of these compounds were found to be biologically important. However, further research is still required to confirm the potential antimicrobial properties of the propolis’ bioactive compounds.

You have full access to the following eBook
You might also be interested in these eBooks

Info:

* - Corresponding Author

[1] S.N.A.S. Salleh, W.L.W. Johari, N.A.M. Hanapiah, A comprehensive review on chemical compounds, biological actions and potential health benefits of stingless bee propolis, Sains Malays. 51 (2022) 733-745.

DOI: 10.17576/jsm-2022-5103-08

Google Scholar

[2] A. Sulaeman, A.M. Fikri, N. Kalsum, M. Mahani, Chapter 25 - Trigona propolis and its potency for health and healing process, in: R.B. Singh, R.R. Watson, T. Takahashi (Eds), The role of functional food security in global health, Academic Press, Cambridge, Massachusetts, United States, 2019, pp.425-448.

DOI: 10.1016/b978-0-12-813148-0.00025-6

Google Scholar

[3] J.A.I. Devi, A.K. Muthu, Gas chromatography mass spectrometry analysis of bioactive constituents in the ethanolic extract of Saccharum spontaneum Linn., Int. J. Pharm. Pharm. Sci. 6 (2014) 1-23.

Google Scholar

[4] M. Trianto, H. Purwanto, Morphological characteristics and morphometrics of Stingless Bees (Hymenoptera: Meliponini) in Yogyakarta Indonesia, Biodiversitas 21 (2020) 2619-2628.

DOI: 10.13057/biodiv/d210633

Google Scholar

[5] C. Ignea, E. Ioannou, P. Georgantea, S. Loupassaki, F.A. Trikka, A.K. Kanelis, A.M. Makris, V. Roussi, S.C. Kamprani, Reconstructing the chemical diversity of labdane-type diterpene biosynthesis in yeast, Metab. Eng. 28 (2015) 91-103.

DOI: 10.1016/j.ymben.2014.12.001

Google Scholar

[6] M.M. Sachitanand, N.G. Hosahudya, Thioacetic acid/NASH-mediated synthesis of N-protected amino thioacids and their utility in peptide synthesis, J. Org. Chem. 79 (2014) 2377-2383.

DOI: 10.1021/jo402872p

Google Scholar

[7] K. Tayjanov, N.Z. Mamadalieva, M. Wink, Diversity of the mountain flora of central asia with emphasis on alkaloid-producing plants, Diversity 9 (2017) 11.

DOI: 10.3390/d9010011

Google Scholar

[8] A.T. Getachew, C. Jacobsen, S.L. Holdt, Emerging technologies for the extraction of marine phenolics: opportunities and challenges, Mar. Drugs. 18(8) (2020) 389.

DOI: 10.3390/md18080389

Google Scholar

[9] L. Paiva, E. Lima, A.I. Neto, M. Marcone,J. Baptista, Nutritional and functional bioactivity value of selected azorean macroalgae: Ulva Compressa, Ulva Rigida, Gelidium Microdon, and Pterocladiella Capillacea, J. Food Sci. 82 (2017) 1757-1764.

DOI: 10.1111/1750-3841.13778

Google Scholar

[10] J. Cotas, D. Pacheco, A.M. Gonçalves, P. Silva, L.G. Carvalho, L. Pereira, Seaweeds' nutraceutical and biomedical potential in cancer therapy: a concise review, J. Cancer Metastasis Treat. 7 (2021) 13.

DOI: 10.20517/2394-4722.2020.134

Google Scholar

[11] S.I. Anjum, A. Ullah, K.A. Khan, M. Attaullah, H. Khan, H. Ali, M.A. Bashir, M. Tahir, M.J. Ansari, H.A. Ghramh, Composition and functional properties of propolis (bee glue): A review, Saudi J. Biol. Sci. 7 (2018) 1695–1703.

DOI: 10.1016/j.sjbs.2018.08.013

Google Scholar

[12] T.G. do Nascimento, R.E. dos Santos Arruda, E.T. da Cruz Almeida, J.M. dos Santos Oliveira, I.D. Basílio-Júnior, I.C.C. de MoraesPorto, A.R. Rodriges Sabino, J. Tonholo, A. Gray, R.E. Edrada Ebel, Comprehensive multivariate correlations between climatic effect, metabolite-profile, antioxidant capacity and antibacterial activity of Brazilian red propolis metabolitesduring seasonal study, Sci. Rep. 9 (2019) 18293.

DOI: 10.1038/s41598-019-54591-3

Google Scholar

[13] S. Gardini, D. Bertelli, L. Marchetti, R. Graziosi, D. Pinetti, M. Plessi, G.L. Marcazzan, Chemical composition of Italian propolisof different ecoregional origin, J. Apic. Res. 57 (2018) 639-647.

DOI: 10.1080/00218839.2018.1494911

Google Scholar