Fabrication of Turmeric Powder-Loaded Silk Fibroin Film for Wound Healing Application

Abstract:

Background: Currently silk fibroin is used more and more in the biomedical researches, including a potential research direction in creating wound dressing. Turmeric powder is a natural drug with many properties suitable for treatment of burns such as anti-inflammatory, anti-bacterial, anti-fungal, especially reducing formation of scars. Methods: In this study, sericin is removed from the silk to obtain fibroin fiber. Fibroin fiber and turmeric powder are dissolved by formic acid adding calcium chloride (CaCl₂). Created fibroin films (FF) are then evaluated in some characteristics such as surface structure, chemical structure, tensile strength, absorbency, dehydration rate, biodegradation ability, pH determination, preventing bacteria ability and cytotoxicity test. Results: All results indicated that created FF is fulfilled with all the required properties of wound dressings. Conclusions: This study is the first step to creating foundation and orientation for the development of commercial wound dressings.

• Periodical: Journal of Biomimetics, Biomaterials and Biomedical Engineering (Volume 44)
• Pages: 63-72
• DOI: https://doi.org/10.4028/www.scientific.net/JBBBE.44.63
• Online since: February 2020
• Authors: Vu Nguyen Doan*, Tung Thanh Truong, Ha Le Bao Tran
• Keywords: Burn Treatment, Silk Fibroin, Turmeric Powder, Wound Dressing

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