Important Aspects of Staging of Biofilm’s Formation and Justification of Time Intervals of Conduction of Prophylactics of Infectious Complications

Abstract:

In this article there are presented materials regarding problems of infectious complications, that appear as the result of formation of microbial biofilms, which is especially actual in medical practice nowadays because of wide usage of different invasive materials in surgical and traumatological and orthopedical departments of clinics. Classifications, which are based on works of many authors, of surgical infections are given, and also of pathogens, known nowadays, of which Staphylococcus aureus и S. epidermidis are superior. Stages of process and laboratory-experimental proven time intervals and special features of biofilm’s formation are determined, which points to an importance and perspectivity of prophylaxis of infectious complications at moments of contaminations and primary adhesion. In light of usage in implantational surgery of constantly advancing materials, the contemplation is necessary of biofilmforming features of known pathogenic and opportunistic bacterias and potentially dangerous, in particular, pathogens that lead to generalization of process.

• Periodical: Journal of Biomimetics, Biomaterials and Biomedical Engineering (Volume 46)
• Pages: 17-24
• DOI: https://doi.org/10.4028/www.scientific.net/JBBBE.46.17
• Online since: June 2020
• Authors: Tatyana Timokhina*, Natalya Perunova, Olga Malyugina, Ilnara Khamitova, Marina Maslova
• Keywords: Biofilms, Infectious Complications, Microorganisms, Prophylactics of Infectious Complications

References

[1] Kuznetsov O.U. Bacterial colony as difficult organized community of cells. Microbiology Journ. 2005; 2: 3-7.

[2] Shipizina I.V., Osipova E.V. Biofilm-forming ability of strains of Staphylococcus aureus and Pseudomonas aeruginosa and their associations obtained in vitro from wounds of patients with acute osteomyelitis. Successes of Modern Natural Science. 2014; 11-3: 18-21.

[3] Sukhorukov V.P. Antibiotic prophylactics in surgery (Prophylactics of infection in region of surgical involvement): Manual for Doctors. Kirov: Kirov's State Medical Academy, 2006: 40.

[4] Golub A.V. Bacterial biofilms – a new goal of therapy? Clinical Microbiological Antimicrobial Chemotherapy; 2012: 1. - 23-29.

[5] Henk J.B. Biomaterial-Associated Infection: Locating the Finish Line in the Race for the Surface. Science Translational Medicine. 2012; l (4): 1-10.

[6] Gabrielyan N.I., Arefyeva L.I., Gorskaya E.M. et al. To the problem of prevention of hospital infection in conditions of development of antibiotic resistant microorganisms. J. Matter of Disinfection. 2015; 2: 25-31.

[7] Markov A.A. Problems of the surgical treatment of patients with fractures of the proximal femur on the basis of osteoporosis. Sys. Rev. Pharm. 2019; 10(1): 143-145.

[8] Manual guide on endoprosthetics of articulatio coxae / Edit. By R.M. Tikhilov, V.M. Shapovalov. – SPb, 2008: 341.

[9] Jiang X., Pace J.L. Microbial Biofilms. In: Biofilms, Infection and Antimicrobial Therapy. Boca Raton, FL, USA, 2006; 3-19.

DOI: 10.1201/9781420028232.sec1

[10] Arciola C.R. Biofilm formation in Staphylococcus implant infections. A review of molecular mechanisms and implications for biofilm-resistant materials. Biomaterials. 2012; 33 (26): 5967-5982.

DOI: 10.1016/j.biomaterials.2012.05.031

[11] Baimagambetov S.A., Balgazarov A.S., Ramazanov Z.K., Markov A.A., Ponomarev A.A., Turgumbayeva R.K. Abdikarimov M.N. Modern models of endoprostheses and periprosthetic infection. Biomedical Research (India). 2018; 29: Iss.11.

DOI: 10.4066/biomedicalresearch.37-18-476

[12] Fischenko P.Y. Actual problems of children's orthopedics and traumatology. Almanac of Clinical Medicine. М., 2003; T. VL: 458-468.

[13] Markov A.A., Timokhina T.H., Perunova N.B., Malyugina O.A. Production technique of bifidobacterium's exometabolites with high antimicrobial activity towards Staphylococcus aureus. Sys. Rev. Pharm. 2020; 11(2): 273-277.

[14] Cherniy V.N. Perspectives of application of biodegradable alloys on the basis of magnum in osteosynthesis. Zaporozhe's Medical Journal. 2013; 6 (81): 76-79.

[15] K̶ck R., Becker K., Cookson B. et al. Methicillinresistant Staphylococcus aureus (MRSA): burden of disease and control challenges in Europe. Euro Surveill. 2010; 15 (41): 19688.

[16] Watnick P., Kolter R. Biofilm, city of microbes J. Bacteriology. 2000; 182: 2675-2679.

DOI: 10.1128/jb.182.10.2675-2679.2000

[17] Trampuz A., Widmer A.F. Iinfections associated with orthopedic implants. Curr. Opin. Infect. Dis. 2006: 19 (4): 349-356.

[18] Buzoleva L.S., Pooz A.V., Sinebrukhov S.L., Gnedenkov S.V. et al. Implant associated infections connected with the problem of biofilm's formation. Modern Problems of Science and Education. 2016; 5.

[19] Lin M., Chang F., Hua M., Wu Y. Inhibitory effects of 1,2,3,4,6-penta-O-Galloyl-β-d-glucopyranose on biofilm formation by Staphylococcus aureus. Antimicrob Agents Chemother 2011; 55:1021-7.

DOI: 10.1128/aac.00843-10

[20] Marrie T.J., Nelligan J., Costerton J.W. A scanning and transmission electron microscopic study of an infected endocardial pacemaker lead. Circulation. 1982; 66: 1339-1341.

DOI: 10.1161/01.cir.66.6.1339

[21] Seregina N.V. The review of biophysical features of microbial adhesion. Herlad of New Medical Technologies. 2008; XV (3): 7-9.

[22] Lebeaux D., Ghigo J.-M., Beloin C. Biofilm-Related Infections: Bridging the gap between clinical management and fundamental aspects of recalcitrance toward antibiotics. Microbiology and Molecular Biology Reviews. 2014; 78 (30): 510-543.

DOI: 10.1128/mmbr.00013-14

[23] Gbejuade H.O., Lovering A.M., Webb J.C. The role of microbial biofilms in prosthetic joint infections. Acta Orthop. 2015; 86 (2). - 147-158.

DOI: 10.3109/17453674.2014.966290

[24] Raja A.F., Furqan A., Inshad A. Kh. et al. Antistaphylococcal and biofilm inhibitory activities of acetyl-11-keto-β-boswellic acid from Boswellia serrata. BMC Microbiology. 2011; 11:1-9.

DOI: 10.1186/1471-2180-11-54

[25] Glushanova N.A., Blinov A.I., Alekseeva N.B. Bacterial biofilms in infectious pathology of a man. Medicine in Kuzbass; 2015; 10: 2-3.

[26] Horan T.C., Gaynes R.P., Martone W.J. et al. CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Infect. Control. Hosp. Epidemiol. 1992; 13: 606-608.

DOI: 10.1086/646436

[27] Struchkov V.I., Gostischev V.K., Struckov U.V. Manual in purulent surgery. М.: Medicine, (1984).

[28] Pathare N.A., Tejani S., Asogan H., Al Mahruqi G. et al. Comparison of methicillin resistant Staphylococcus aureus in healthy community hospital visitors [CA-MRSA] and hospital staff [HA-MRSA]. Mediterr. J. Hematol. Infect. Dis. 2015; 7(1).

DOI: 10.4084/mjhid.2015.053

[29] Brusina E.B., Dmitrienko O.A., Glazovskaya L.S., Efimova T.V. Epidemiology and epidemiological monitoring of infections caused by Methicillin resistant strains of Staphylococcus aureus. Federal Clinical Recommendations. M., (2014).

[30] Vinnick U.S., Serova E.V., Andreev R.I. Specialties of formation of microbial biofilms over different substrates. The possibility of study of biofilms on the biliary concretions. Modern Problems of Science and Education. 2013: 5.

[31] Bojkova S.A., Tikhilov R.M., Krasnova M.V. Orthopedic implant-associated infection: leading pathogens, local resistance and recommendations on antibacterial therapy. Traumatology and Orthopedics of Russia. 2013; 4.

DOI: 10.21823/2311-2905-2013--4-5-15

[32] Brendamari R., Romero A. Biomaterials for orthopedics. Applications of Engineering Mechanics in Medicine. (2004).

[33] Shkodkin S.V., Jernakova N.I., Idashkin U.B. Several aspects of nosocomial infection // Scientific Statements of Belgorod's State University. 2013; 4 (147): 5-11.